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Effects of 0.2 parts per million nitrogen di oxide on pulmonary function and response to broncho provocation in asthmatics



Effects of 0.2 parts per million nitrogen di oxide on pulmonary function and response to broncho provocation in asthmatics



Journal of Toxicology and Environmental Health 12(4-6): 815-826



To study the respiratory effects of NO2 at ambient concentrations, 31 asthmatic volunteers were exposed to purified air (control) and to 0.2 ppm NO2 for 2-h periods with light intermittent exercise. Bronchial reactivity (loss of forced expiratory performance in repsonse to graded doses of methacholine chloride aerosol) was determined postexposure, using a newly developed apparatus that allowed accurate quantitation of methacholine dose. Forced expiratory performance, total respiratory resistance and symptoms were also recorded immediately pre- and postexposure (prior to methacholine challenges). No significant direct effect of NO2 exposure on forced expiratory function or total respiratory resistance was observed. Symptoms showed a small significant (P < 0.05) excess in purified air relative to NO2 exposures. Individual responses to methacholine varied greatly. Of the subjects, .apprx. 2/3 showed greater response after NO2 than after purified air but the mean excess response was small. Mean changes attained significance in some but not all applicable statistical tests. Thus, NO2 exposure may not have increased bronchial reactivity in this group although there was some tendency in that direction.

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Accession: 005285398

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