Effects of active amines on development of stress ulcers: review of noradrenalin, 5-hydroxytryptamine and histamine levels in brain and gastric wall of restrained and cold exposed rats

Kodama, M.; Ito, N.; Kodama, O.; Ogawa, Y.; Kato, Y.; Matsuyama, T.; Yoshida, H.; Ezaki, H.

Hiroshima Journal of Medical Sciences 31(1): 37-44


ISSN/ISBN: 0018-2052
PMID: 7096123
Accession: 005287819

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Acute hemorrhagic gastroduodenal ulcers are frequently induced by various types of stress. With the purpose of studying CNS factors and gastric mucosal local factors involved in the development of such ulcers, Wistar strain rats were subjected to restraint and cold exposure for 120 min and the intragastric pH, the noradrenaline , 5-hydroxytryptamine and histamine contents in the brain and gastric wall were measured over time. The intragastric pH decreased with time up to 120 min, but the difference with the prerestraint value was not significant. At 60 min after restraint, when the ulcerogenic rate became markedly increased, the noradrenaline content of the amines in the brain showed a significant decrease, while 5-hydroxytryptamine increased significantly, but the histamine value failed to show any significant change. The histamine level of the amines in the gastric wall decreased significantly after 30 min and the 5-hydroxytryptamine value showed a significant decrease after 60 min. The effects of gastric acid on the development of acute hemorrhagic gastroduodenal ulcers are probably small. However, of the amines in the brain, the changes in the values of noradrenaline and 5-hydroxytryptamine and of those in the gastric wall, the changes in 5-hydroxytryptamine and histamine levels apparently had important implications.