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Effects of chronic alpha and beta adrenoceptor blockade with labetalol on plasma catecholamines and renal function in hypertension



Effects of chronic alpha and beta adrenoceptor blockade with labetalol on plasma catecholamines and renal function in hypertension



Klinische Wochenschrift 58(1): 25-30



Plasma catecholamines and renal function were evaluated in 18 patients with essential hypertension treated with the.alpha.- and.beta.-adrenoceptor blocking agent, labetalol. After 6 wk of labetalol therapy, blood levels of epinephrine and norepinephrine remained unaltered. Glomerular filtration rate and renal plasma flow were decreased similarly by.apprx. 20%. Tubular rejection fraction of Na was increased by 36% while Na excretion was comparable to control conditions.

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Accession: 005295490

Download citation: RISBibTeXText

PMID: 7374093

DOI: 10.1007/bf01477140


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