Effects of d l alpha amino adipate on synaptic transmission in spinal inter neurons of the lamprey lampetra japonica
Journal of Comparative Physiology A Sensory Neural and Behavioral Physiology 143(4): 423-426
In the giant interneurons of the spinal cord of the lamprey, L. japonica, a primitive vertebrate, DL-.alpha.-aminoadipate, 3-5 mM, reversibly depressed both the monosynaptic EPSP [excitatory postsynaptic potential] and the depolarization produced by iontophoretic application of glutamate or aspartate. The monosynaptic EPSP was produced by intracellular stimulation of caudal giant interneurons. L-glutamate diethylester also depressed the monosynaptic excitation and aspartate and glutamate potentials but 10-20 mM was necessary. Acidic amino acids or closely related substances may be serving the mutual excitation between giant interneurons of the lamprey spinal cord.