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Effects of dietary methionine taurine cystine and glycine on liver and serum lipids in rats fed with a histidine excess diet



Effects of dietary methionine taurine cystine and glycine on liver and serum lipids in rats fed with a histidine excess diet



Agricultural & Biological Chemistry 52(4): 1027-1032



Feeding with a 3.5% histidine diet caused hypercholesterolemia, heptomegaly and decreased lipid content in the liver of rats. The addition of 1.0% L-methionine to the 3.5% histidine diet caused increases in liver lipids and serum total cholesterol as compared with those in rats fed with the 3.5% histidine diet. The addition of 1.0% L-cystine to the 3.5% histidine diet caused an increase in serum total cholesterol compared with that in rats fed with the 3.5% histidine diet, but the addition of taurine had no effect on serum and liver lipids. The addition of 2.5% or 5.0% glycine to the 3.5% histidine diet decreased serum total and HDL cholesterol compared with that in rats fed with the 3.5% histidine diet.

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