Effects of histamine and cimetidine on chloride secretion in isolated monkey gastric mucosa
Wang, M.D.
Zhongguo Yao Li Xue Bao 6(3): 175-177
1985
ISSN/ISBN: 0253-9756 PMID: 2943120 Accession: 005307314
The stripped gastric mucosa of Rhesus monkeys were used to study electrical properties and chloride secretion. A potential difference (PD) across the mucosal membrane was seen with serosa being electropositive. The magnitude of PD and short-circuit current (ISC) were found to be close to that of dog gastric mucosa. At resting state, C1- was secreted from serosal to mucosal side, and this secretion was greatly stimulated by histamine. Cimetidine completely blocked the stimulating effect of histamine on Cl- secretion.