+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of interstimulus interval and contingency of classical conditioning of the aplysia siphon withdrawal reflex



Effects of interstimulus interval and contingency of classical conditioning of the aplysia siphon withdrawal reflex



Journal of Neuroscience 6(6): 1695-1701



The siphon withdrawal reflex of Aplysia undergoes differential classical conditioning with cutaneous stimulation of the siphon or mantle shelf as the discriminative conditioned stimuli (CS+ and CS-) and shock to the tail as the unconditioned stimulus (US). The reflex has proved to be useful for analyzing the neural mechanisms of conditioning. To test the generality of this experimental system, we have begun to compare the properties of conditioning in Aplysia with those of conditioning in vertebrates. We first examined the effect of the interstimulus interval (ISI) by varying the time between presentation of the CS+ and the US in different groups of animals. Significant differential conditioning was obtained when the onset of the CS+ preceded the onset of the US by 0.5 sec, and marginal conditioning was obtained when the ISI was 1.0 sec. By constrast, no significant conditioning occurred when the CS+ preceded the US by 2, 5, or 10 sec, when the onsets of the stimuli were simultaneous, or when US onset preceded the CS+ by 0.5, 1.0, or 1.5 sec (backward conditioning). We next examined the effect of contingency by giving one group of animals normal differential conditioning, and a second group the same training but with additional USs inserted between the paired trails. Presentation of these additional USs reduced the degree to which the US was contingent on the CS+, but did not change the number of pairings. Animals receiving normal training again showed significant conditioning, whereas animals receiving additional USs showed no conditioning. The results of these experiments indicate that conditioning of the Aplysia siphon withdrawal reflex is similar to conditioning in vertebrates in two major respects: the effects of interstimulus interval and contingency. It may therefore be possible to begin to analyze the neural mechanisms of these features of conditioning in Aplysia.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 005309869

Download citation: RISBibTeXText

PMID: 3712005


Related references

Effects of interstimulus interval and contingency on classical conditioning of the Aplysia siphon withdrawal reflex. The Journal of Neuroscience 6(6): 1695-1701, 1986

Classical conditioning of the Aplysia siphon-withdrawal reflex exhibits response specificity. Proceedings of the National Academy of Sciences of the United States of America 86(19): 7620-7624, 1989

Contribution of pre- and postsynaptic mechanisms to activity-dependent facilitation during classical conditioning of the Aplysia siphon-withdrawal reflex. Society for Neuroscience Abstracts 26(1-2): Abstract No -568 2, 2000

Activity-dependent facilitation of monosynaptic sensory neuron-motor neuron PSPs contributes to classical conditioning of the Aplysia siphon-withdrawal reflex in a simplified preparation. Society for Neuroscience Abstracts 25(1-2): 1129, 1999

Differential classical conditioning of tail and siphon withdrawal in aplysia. Society for Neuroscience Abstracts 10(1): 270, 1984

Role of nitric oxide in classical conditioning of siphon withdrawal in Aplysia. Journal of Neuroscience 27(41): 10993-11002, 2007

Classical conditioning of aplysia siphon withdrawal involves the development of a new response to the cs. Society for Neuroscience Abstracts 15(2): 1264, 1989

Classical conditioning, differential conditioning, and second-order conditioning of the Aplysia gill-withdrawal reflex in an isolated mantle organ preparation. Society for Neuroscience Abstracts 19(1-3): 17, 1993

Classical conditioning, differential conditioning, and second-order conditioning of the Aplysia gill-withdrawal reflex in a simplified mantle organ preparation. Behavioral Neuroscience 112(3): 636-645, 1998

Classical conditioning in a simple withdrawal reflex in Aplysia californica. Journal of Neuroscience 1(12): 1426-1437, 1981

The in vitro Classical Conditioning of the Gill Withdrawal Reflex of Aplysia californica. Science 212(4502): 1516-1518, 1981

Contribution of monosynaptic EPSPS from LE siphon sensory neurons to mediation and habituation of the gill- and siphon withdrawal and reflex in Aplysia. Society for Neuroscience Abstracts 22(1-3): 1445, 1996

Effects of increasing the interstimulus interval during classical conditioning of the albino rabbit. Journal of Comparative and Physiological Psychology 60(2): 249-252, 1965

In vitro classical conditioning of the aplysia californica gill withdrawal reflex involves multiple mechanisms. Society for Neuroscience Abstracts 12(2): 860, 1986

Classical conditioning and retention of the infant's eyelid response: effects of age and interstimulus interval. Journal of Experimental Child Psychology 37(3): 512-524, 1984