Effects of ionizing radiations on human costal cartilage and exploration of the procedures to protect the tissue from radiation damage

Edwards, H.E.; Moore, J.S.; Phillips, G.O.

Histochemical Journal 10(4): 389-398

1978


ISSN/ISBN: 0018-2214
PMID: 669981
DOI: 10.1007/bf01003002
Accession: 005310504

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Abstract
Chemical changes produced following 60Co-.gamma.-irradiation of human costal cartilage were monitored using critical electrolyte concentration (CEC) measurements utilizing alcian blue-MgCl2 and toluidine blue-NaCl systems. The decrease in the CEC with radiation was related to the decrease in hexose and hexosamine contents of the cartilage. Such changes arise as a result of degradation of the glycosaminoglycan component of the tissue. The state of the collagen fibers after irradiation was examined using the Van Giesson stain and by biochemical assay of the hydroxyproline moeity. Energy transfer methods were utilized to protect the glycosaminoglycan component of the cartilage from radiation damage.

Effects of ionizing radiations on human costal cartilage and exploration of the procedures to protect the tissue from radiation damage