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Effects of lidocaine and its n dealkylated metabolite on the response of isolated rabbit aorta to trans mural stimulation


Effects of lidocaine and its n dealkylated metabolite on the response of isolated rabbit aorta to trans mural stimulation



Bulletin of the Yamaguchi Medical School 28(3-4): 89-98



ISSN/ISBN: 0513-1812

Contractile responses of rabbit aortic strips to transmural stimulation and to exogenously applied norepinephrine (NE), KCl and histamine were studied in the presence of lidocaine or its metabolite, glycinexylidide (GX). Lidocaine, 10-4 and 5 .times. 10-4 M, attenuated the contractile response to transmural stimulation. GX, 2 .times. 10-5-5 .times. 10-4 M, potentiated the response to transmural stimulation. The suppression induced by lidocaine was not reversed by excess Ca, 2.2 and 4.4 mM, but was partially reversed by cocaine, 3 .times. 10-6 M. Lidocaine, 5 .times. 10-4 M shifted the dose-response curve of NE to the right; GX, 5 .times. 10-4 M, shifted the curve to the left. The maximum tension developed by K+ was attenuated by lidocaine, 5 .times. 10-4 M, and GX, 2 .times. 10-3 M. Evidently lidocaine attenuates the response to stimulation of sympathetic nerves innervating the arterial wall by interfering with NE release. GX potentiates the response, possibly by increasing NE release.

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Accession: 005311791

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