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Effects of lilly 110140 3 p tri fluoromethylphenoxy n methyl 3 phenylpropylamine hydro chloride a specific inhibitor of 5 hydroxy tryptamine uptake on food intake and on 5 hydroxy tryptophan induced anorexia evidence for serotoninergic inhibition of feeding


Journal of Pharmacy and Pharmacology 28(4): 318-320
Effects of lilly 110140 3 p tri fluoromethylphenoxy n methyl 3 phenylpropylamine hydro chloride a specific inhibitor of 5 hydroxy tryptamine uptake on food intake and on 5 hydroxy tryptophan induced anorexia evidence for serotoninergic inhibition of feeding
The involvement of serotoninergic neurons in 5-HTP [5-hydroxytryptophan] induced anorexia was investigated, utilizing a recently discovered inhibitor of the uptake pump in 5-HT [5-hydroxytryptamine] neurons, Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine hydrochloride. Lilly 110140 has a potent anorectic effect of short duration in rats and potentiates the anorectic effects of 5-HTP. This potentiation was observed even after the anorectic effect of Lilly 110140 had completely off (between 2 and 6 h after food access), indicating that the potention of 5-HTP anorectic effects observed in the Lilly 110140-5-HTP group is not solely due to the synergic anorectic effects of Lilly 110140 and 5-HTP but is also a consequence of specific inhibition of 5-HT uptake pump. Serotoninergic neurons are directly implicated in the anorectic effects of 5-HTP.

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Accession: 005312038



Related references

Effects of Lilly 110140, a specific inhibitor of 5-hydroxytryptamine uptake, on food intake and on 5-hydroxytryptophan-induced anorexia. Evidence for serotoninergic inhibition of feeding. Journal of Pharmacy and Pharmacology 28(4): 318-320, 1976

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