EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effects of loperamide on the motility of the isolated intestine in guinea pigs, rats and dogs






Nihon Heikatsukin Gakkai Zasshi 13(2): 69-74

Effects of loperamide on the motility of the isolated intestine in guinea pigs, rats and dogs

Effects of Loperamide on the motility of the isolated intestine in guinea-pigs, puppies and rats were examined. The spontaneous contractions of the small intestine and colon in puppies were inhibited at relatively high concentration of the agent (10(-5) g/ml). The peristaltic reflex in the guinea-pig ileum was slightly inhibited at concentrations of 10(-8) to 10(-7) g/ml, and was completely abolished at 10(-6) g/ml. The agent (2X10(-7) g/ml) inhibited the longitudinal contraction of the guinea-pig ileum elicited by transmural electric stimulation. The agent (10(-5) g/ml) inhibited the acetylcholine-induced contraction of the colon and small intestine in puppies, and induced the hyperpolarization of the membrane potential and the abolition of spike potentials of the intestinal muscle in rats.

(PDF 0-2 workdays service: $29.90)

Accession: 005312690

PMID: 916439



Related references

P C O2 in the large intestine of mice, rats, guinea pigs, and dogs and effects of the dietary substrate. Journal of Applied Physiology 92(1): 9-24, 2002

PCO(2) in the large intestine of mice, rats, guinea pigs, and dogs and effects of the dietary substrate. Journal of Applied Physiology 92(1): 219-224, 2001

Effects of morphine upon the isolated small intestine of rats, rabbits and guinea pigs. Japanese Journal of Physiology 16(5): 528-540, 1966

Pharmacological studies of loperamide, an anti-diarrheal agent. II. Effects on peristalsis of the small intestine and colon in guinea pigs. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 74(1): 155-163, 1978

Pharmacological studies of loperamide an anti diarrheal agent part 2 effects on peristalsis of the small intestine and colon in guinea pigs. Folia Pharmacologica Japonica 74(1): 155-163, 1978

Paradoxical action of some tetraethylammonium compounds on tonus and motility of isolated intestine of guinea pigs. Archivos del Instituto de Farmacologia Experimental 8(1-2): 176-185, 1955

Effects of nicotine receptor agonists on acetylcholine release from the isolated motor nerve small intestine and trachea of rats and guinea pigs. Clinical Investigator. 70(3-4): 182-189, 1992

Motility of the isolated oviduct of rats and guinea pigs. Basic Life Sciences 4(Pt. B): 147-158, 1974

The effects of serotonin on the motility of small and large intestine of guinea pigs in fasting. Turk Veterinerlik ve Hayvanclk Dergisi 27(1): 273-280, 2003

Effects of cisapride on the motility of digestive tract in dogs and guinea pigs. Japanese Journal of Smooth Muscle Research 21(1): 1-10, 1985