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Effects of methyl vitamin b 12 on the in vitro immune functions of human t lymphocytes


Journal of Clinical Immunology 2(2): 101-109
Effects of methyl vitamin b 12 on the in vitro immune functions of human t lymphocytes
Studies were performed using an in vitro assay system to determine whether or not methyl-B12 could affect human T-cell function. When T cells were stimulated with phytohemagglutinin and allogeneic B cells, methyl-B12 did not enhance T-cell proliferation. Remarkable enhancing effects of methyl-B12 on the proliferative response to concanavalin A (Con A) and autologous B cells at suboptimal concentrations were observed, ranging from 0.1-10 .mu.g/ml. Concentrations of methyl-B12 sufficient to enhance cellular proliferation were able to enhance the activity of helper T cells for Ig synthesis of B cells by pokeweed mitogen. The presence of methyl-B12 significantly potentiated the induction of suppressor cells in Con A-activated cultures. Methyl-B12 could modulate lymphocyte function through augmenting regulatory T-cell activities.


Accession: 005314196



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