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Effects of metoclopramide on maternal umbilical and amniotic fluid prolactin at delivery

Effects of metoclopramide on maternal umbilical and amniotic fluid prolactin at delivery

Folia Endocrinologica Japonica 58(12): 1544-1552

Sixteen normal pregnant woman at delivery were administered 10mg of metoclopramide (MCP) i.v., and the prolactin (PRL) levels in the maternal plasma and in the amniotic fluid were measured by radioimmunoassay before and after the administration, and in the umbilical plasma after the administration. Eight other pregnant women at term were studied similarly without the administration of MCP and served as controls. There was a significant increase only in the maternal plasma PRL but not in the amniotic fluid PRL nor in the umbilical plasma PRL. By using an intrauterine pressure catheter and a maternal i.v. canule the amniotic fluid PRL and the maternal plasma PRL were measured about every 20 minutes during 3 h before and after the i.v. administration of 10mg MCP. The maternal plasma PRL increased promptly and remained high for 150 min, while there was no significant change in the amniotic fluid PRL. Decidua apparently is the source of amniotic fluid PRL; an independent regulation of amniotic fluid PRL is suggested.

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