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Effects of milbemycin d on the motility of angiostrongylus cantonensis and angiostrongylus costaricensis



Effects of milbemycin d on the motility of angiostrongylus cantonensis and angiostrongylus costaricensis



Japanese Journal of Parasitology 35(6): 497-504



Effects of a new anthelmintic, milbemycin D on the motility of A. cantonensis and A. costaricensis were examined. 1) Milbemycin D paralyzed A. cantonensis at 10-11 g/ml and greater, but did not affect A. costaricensis even at 10-6 g/ml. 2) The paralyzing action of milbemycin D on A. cantonensis was antagonized by gabergic antagonists such as picrotoxin and bicuculline, but not by .alpha.-adrenergic antagonists like dibenamine and phentolamine. Between these bicuculline was found to be more effective than picrotoxin. In the preparation paralyzed with milbemycin D, only a slight and transient contraction was produced by eserine, but a strong and sustained contraction was caused after the combined application of eserine and picrotoxin. These results suggest that milbemycin D causes paralysis in A. cantonensis probably through the gabergic mechanism like avermectins. 3) In vitro motility was examined on adult female worms which were pretreated in vivo with milbemycin D. From the degree of their motility and responses to eserine and picrotoxin, it was shown that milbemycin D had little effect on A. costaricensis pretreated in vivo with a single oral dose of 25.0 mg/kg, but the drug was notably effective on A. cantonensis at 1.0 to 5.0 mg/kg. Thus, we could select the doses around 5.0 mg/kg to examine more reasonably in vivo activities of milbemycin D against these blood nematodes.

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