EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effects of morphine and naloxone on inhibition by ovarian hormones of pulsatile release of luteinizing hormone in ovariectomized rats


Neuroendocrinology 34(4): 269-273
Effects of morphine and naloxone on inhibition by ovarian hormones of pulsatile release of luteinizing hormone in ovariectomized rats
The effects of morphine and naloxone on pulsatile release of LH [luteinizing hormone] in ovariectomized rats treated (or untreated) with ovarian steroids were studied. Ovariectomized rats were given a s.c. injection of estradiol benzoate (20 .mu.g) or estradiol benzoate (20 .mu.g) and progesterone (10 mg) 3 days prior to experimentation. The rats were then given i.v. injections of naloxone (2 mg/kg), morphine (5 mg/kg), or 0.87% NaCl every hour for 3 h. For LH assays, 0.3 ml blood was collected via an atrial cannula 15 min after drug treatment and every 15 min thereafter for 3 h. Pulsatile LH release was suppressed by estradiol benzoate or the combination of estradiol benzoate and progesterone. Naloxone was able to counteract inhibition of pulsatile LH release by these steroids. Apparently the endogenous opioid peptides are involved in the negative feedback exerted by estrogen and progesterone on pulsatile LH release. Morphine had no effect on steroid inhibition of pulsatile LH release.


Accession: 005314938



Related references

Effects of morphine and naloxone on inhibition by ovarian hormones of pulsatile release of LH in ovariectomized rats. Neuroendocrinology 34(4): 269-273, 1982

Effect of manipulation of brain dopaminergic or serotoninergic systems on basal pulsatile luteinizing hormone release and peri suprachiasmatic induced suppression of pulsatile luteinizing hormone release in ovariectomized rats. Neuroendocrinology 31(3): 161-167, 1980

Effects of neo natal mono sodium glutamate on pulsatile plasma luteinizing hormone and estrogen feedback on luteinizing hormone release in ovariectomized rats. Physiologist 21(4): 114, 1978

Role of central serotonin systems in the stimulatory effects of ovarian hormones and naloxone on luteinizing hormone release in female rats. Endocrinology 118(3): 1180-1186, 1986

Studies on the feedback regulation of pulsatile luteinizing hormone secretion effect of ovarian steroid implantation into the forebrain and basal hypothalamus on pulsatile luteinizing hormone secretion in ovariectomized rats. Folia Endocrinologica Japonica 61(1): 22-37, 1985

Effects of stress on pulsatile luteinizing hormone release in ovariectomized rats. Proceedings of the Society for Experimental Biology and Medicine 148(3): 813-815, 1975

Concomitant inhibition of pulsatile luteinizing hormone (LH) and stimulation of prolactin release by prostacyclin (PGI2) in ovariectomized (OVX) conscious rats. Life Sciences 43(25): 2077-2085, 1988

Effects of various inhibitors of phenylethanolamine n methyltransferase on pulsatile release of luteinizing hormone in ovariectomized rats. Journal of Endocrinology 111(1): 51-60, 1986

Pulsatile luteinizing hormone patterns in ovariectomized rats involvement of norepinephrine and dopamine in the release of lhrh and luteinizing hormone. Endocrinology 111(3): 932-938, 1982

Vasoactive intestinal polypeptide effects a central inhibition of pulsatile luteinizing hormone secretion in ovariectomized rats. Endocrinology 117(5): 2134-2139, 1985