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Effects of morphine on ca 1 vs. dentate hippocampal field potentials following systemic administration in freely moving rats


Neuropharmacology 21(4): 361-366
Effects of morphine on ca 1 vs. dentate hippocampal field potentials following systemic administration in freely moving rats
Hippocampal field potentials were recorded in vivo before and after a series of incremental doses of morphine (2,6 and 15 mg/kg i.v.) and after a subsequent infusion of 2 mg/kg naloxone. The 15 mg/kg dose of morphine resulted in an augmentation of the field potential recorded in CA1 following stimulation of stratum radiatum, as shown by an increase in the size of the primary spike and the appearance of (an) additional population spike(s). This was the same effect that was previously observed on the same response in the isolated hippocampal slice following bath application of the drug, suggesting that the hippocampal slice is a valid model for the effects of systemically administered opiates in this area of the brain. Morphine generally resulted in an increase in the primary spike only (and no secondary spikes) in the field potentials recorded in dentate following stimulation of the ipsilateral perforant path. Morphine 6 and 15 mg/kg reduced the attenuation of the 2nd response of a paired-pulse paradigm in the radiatum-to-CA1 responses but not in perforant path-to-dentate responses. In 4 out of 16 animals tested the excitatory effects on the field potentials were accompanied by seizure-like activity in the simultaneously recorded cortical and hippocampal EEG, providing further evidence that opiates may mediate convulsive activity in the hippocampus.


Accession: 005314994



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