Effects of nerve growth factor and nerve growth factor antiserum on tyrosine hydroxylase and dihydropterine reductase activities in rat superior cervical ganglia in vivo

Nikodijevic, B.; Yu, M.W.; Guroff, G.

Journal of Neurochemistry 28(4): 851-852

1977


ISSN/ISBN: 0022-3042
PMID: 19564
DOI: 10.1111/j.1471-4159.1977.tb10637.x
Accession: 005315827

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Abstract
The alterations in TH . Under these conditions the regeneration of reduced pteridines does not seem to be limiting for tyrosine hydroxylation. The activity of DHPR is in excess in the ganglia compared to the NGF-stimulated activity of TH. The increase of TH activity after NGF administation is selective since other related enzymes, now including DHPR, do not rise. The action of the antibody must also be selective since enzymes related to TH, such as DHPR, do not decrease. TH and DHPR are not coordinately regulated in mammals.

Effects of nerve growth factor and nerve growth factor antiserum on tyrosine hydroxylase and dihydropterine reductase activities in rat superior cervical ganglia in vivo