Effects of nitroglycerin on the circulatory system, myocardial dynamics and left ventricular oxygen consumption in the anesthetized beagle-dog

Cartheuser, C.F.; Komarek, J.

Basic Research in Cardiology 74(2): 161-176

1979


ISSN/ISBN: 0300-8428
PMID: 112991
DOI: 10.1007/bf01907819
Accession: 005316320

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Abstract
Effects of nitroglycerin (3.0; 6.3 and 10.0/.mu.g/kg i.v.) on the circulatory system, myocardial dynamics and left ventricular O2 consumption were investigated in 10 dogs by thermodilution and catheter techniques following sodium pentobarbital anesthesia. Nitroglycerin induced its maximum effects 1 min after injection and was active, mostly dose-dependent, for 3-5 min. Some effects persisted for .apprx. 20 min. Mean arterial blood pressure in the femoral artery and total peripheral resistance were reduced. Heart rate rose slightly. Positive inotropy was evident from a pronounced increase of dP/dtmax and from a reduction of t-dP/dt, while ejection time was shortened. Respiration rate simultaneously increased for some minutes. Left ventricular systolic pressure (LVP) and end-diastolic pressure (LVEDP) were reduced with a concomitant lasting diminution of ventricular end-systolic volume (LVESV). Stroke volume index and cardiac output index showed a persistent decrease; cardiac work was reduced. Left ventricular O2 consumption was diminished for .apprx. 15 min following an initial increase within the 1st min after nitroglycerin injection. Hemodynamic alterations induced by nitroglycerin are discussed.

Effects of nitroglycerin on the circulatory system, myocardial dynamics and left ventricular oxygen consumption in the anesthetized beagle-dog