Effects of single and prolonged benzene administration on noradrenaline and dopamine content of the rat brain and internal organs

Paradowski, M.; Prioux Guyonneau, M.; Heimburger, M.; Andrzejewski, S.W.; Cohen, Y.

Biogenic Amines 2(3): 191-196


ISSN/ISBN: 0168-8561
Accession: 005325294

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In rats, single subcutaneous (s.c.) administration of benzene in doses 540-2160 mg/kg produced an increase in noradrenaline content of the brain, spleen, liver and kidneys. After prolonged administration of benzene in doses 67.5-540 mg/kg an increase in brain dopamine content and in noradrenaline level of spleen, liver and kidneys. An increase in noradrenaline content of these internal organs reflects an inducing effect of the hydrocarbon on the accumulation processes of this biogenic amine regulated by sympathetic system.