+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effects of total parenteral nutrition enriched with branched chain amino acid infusion on liver function and serum amino acid pattern in dogs undergoing hepatectomy



Effects of total parenteral nutrition enriched with branched chain amino acid infusion on liver function and serum amino acid pattern in dogs undergoing hepatectomy



Ricerca in Clinica e in Laboratorio 15(1): 79-88



To study effects of different total parenteral nutritional regimens on the recovery of liver function and on plasma amino acid pattern after major hepatectomy, 12 healthy mongrel dogs were submitted to 70% liver resection and randomly divided into 3 different groups: group I received only 10% glucose; group II received 10% glucose plus 8.5% Freamine; group III received 10% glucose plus 100% branched chain amino acid (BCAA) solution. Blood samples were analyzed for determining biochemical parameters, including plasma amino acid levels, before surgery and on 3rd and 7th postoperative day. Group III compared to other groups showed higher values of plasma proteins (P < 0.01) and prothrombin activity (P < 0.05) on the 3rd postoperative day. The total concentration of plasma amino acids decreased after hepatectomy. Gluconeogenetic amino acids Al and Glu were markedly decreased in groups II and III, likely due to their increased consumption during gluconeogenesis. Aromatic amino acids were increased in all groups, due to the transient liver insufficiency. BCAA markedly increased in group III on 3rd postoperative day and returned to basal values on 7th postoperative day; possible explantations of such alterations are discussed. BCAA may represent a 1st choice substrate in the early phase after hepatectomy.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 005331371

Download citation: RISBibTeXText

PMID: 3922042

DOI: 10.1007/bf03029165


Related references

Effects of branched chain amino acid-enriched total parenteral nutrition on amino acid utilization in rats bearing Yoshida sarcoma. Cancer Research 48(10): 2698-2702, 1988

The effect of enriched branched chain amino acid solution on amino acid metabolism during perioperative total parenteral nutrition support. Zhonghua Wai Ke Za Zhi 27(12): 756, 1989

Alanylglutamine-enriched total parenteral nutrition improves protein metabolism more than branched chain amino acid-enriched total parenteral nutrition in protracted peritonitis. Journal of Trauma 42(2): 183-190, 1997

Randomized, controlled study of branched chain amino acid-enriched total parenteral nutrition in malnourished patients with gastrointestinal cancer undergoing surgery. American Surgeon 74(3): 237-242, 2008

Intracellular and extracellular amino acid concentrations in portacaval shunted rabbits role of hyperammonemia and effects of branched chain amino acid enriched parenteral nutrition. Zeitschrift fuer Ernaehrungswissenschaft 28(2): 149-172, 1989

Intra- and extracellular amino acid concentrations in portacaval-shunted rabbits. Role of hyperammonemia and effects of branched-chain amino acid-enriched parenteral nutrition. Zeitschrift fur Ernahrungswissenschaft 48(2): 149-172, 1989

Metabolic effects of arginine and branched chain amino acid enriched total parenteral nutrition on walker 256 carcinosarcoma. FASEB Journal 4(4): A1177, 1990

The effect of the administration of an amino acid solution enriched with branched-chain amino acids on the nutritional assessment of patients with stress who require total parenteral nutrition. Nutricion Hospitalaria 8(4): 225-241, 1993

Evaluation of an infusion solution enriched with branched chain amino acid in parenteral nutrition of rats. Journal of Nutrition 110(4): 710-719, 1980

Evaluation of an Infusion Solution Enriched with Branched Chain Amino Acid in Parenteral Nutrition of Rats. The Journal of Nutrition 110(4): 710-719, 1980

Improvements in protein kinetics in cancer cachexia by branched chain amino acid enriched total parenteral nutrition. Clinical Research 33(1): 72A, 1985

Effect of branched-chain amino acid-rich parenteral nutrition on protein metabolism after partial hepatectomy in rats with liver cirrhosis. Nan Fang Yi Ke Da Xue Xue Bao 27(11): 1721-1723, 2007

Total hepatectomy as a model for fulminant hepatic failure effects of branched chain amino acid infusion. Gastroenterology 80(5 Part 2): 1336, 1981

Do branched chain amino acid enriched total parenteral nutrition solutions improve nitrogen balance morbidity or mortality in mildly stressed patients?. Clinical Nutrition 5(SPEC Suppl.): 65, 1986

Effect of glucose and branched chain amino acid (BCAA) infusion on onset of liver regeneration and plasma amino acid pattern in partially hepatectomized rats. Journal of Hepatology 13(1): 14-20, 1991