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Effects of treatment with thiamin antagonists oxy thiamin and pyri thiamin and of thiamin excess on the levels and distribution of thiamin in rat tissues



Effects of treatment with thiamin antagonists oxy thiamin and pyri thiamin and of thiamin excess on the levels and distribution of thiamin in rat tissues



Journal of Nutritional Science & Vitaminology 28(3): 217-224



Levels of thiamin and its derivatives in brain, heart and liver were determined in control, thiamin-deficient, pyrithiamin-treated and oxythiamin-treated rats at various times after the start of treatment. With 10 .mu.g of thiamin/100 g per day s.c. rats rapidly lost thiamin from the tissues until growth maintenance levels were reached. Oxythiamin had a minimal further effect on tissue thiamin while pyrithiamin caused further marked reduction. With higher levels of thiamin intake, tissue thiamin levels increased with intakes of up to 150-200 .mu.g/100 g per day after which they did not show any further significant increase. Levels of pyrithiamin above 50 .mu.g/100 g per day for 20 days had only minimal further effect on tissue thiamin levels over that with 50 .mu.g.

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Accession: 005331660

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PMID: 7131099


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