Effects of various cyclo phosphamide concentrations in vivo on sister chromatid exchanges and chromosome aberrations of chinese hamster bone marrow cells comparison of 2 methods measuring the mutagenicity of a test compound

Roszinsky Koecher, G.; Roehrborn, G.

Human Genetics 46(1): 51-56


ISSN/ISBN: 0340-6717
Accession: 005332771

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The in vivo SCE (sister chromatid exchange) formation and the induction of chromosome aberrations in the bone marrow of Chinese hamsters (Cricetulus griseus) were studied after the administration of various concentrations of cyclophosphamide. The sensitivity of the 2 test methods was compared. Doses of 1.0, 5.0, 13.3, 25.0 and 40.0 mg/kg body weight induced a dose-dependent increase in SCE. The frequency of chromosome aberration was not increased significantly with doses of 1.0 and 5.0 mg/kg body weight. Only doses of > 13.3 mg resulted in a significant induction of chromosome aberrations. The SCE test system is apparently 10 times more sensitive than the induction of chromosome aberrations in the same cell type.