Efficacy of levamisole against the swine kidneyworm, Stephanurus dentatus

Stewart, T.B.; Fincher, G.T.; Marti, O.G.; McCormick, W.C.

American Journal of Veterinary Research 38(12): 2081-2083


ISSN/ISBN: 0002-9645
PMID: 145817
Accession: 005335866

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Two formulations of levamisole HCl were given to sows naturally infected with kidneyworm (S. dentatus): Levamisole HCl in cornmeal was fed to 13 sows at the rate of 8 mg/kg of body weight in a single treatment; levamisole (in solution) was injected s.c. into 10 additional sows at the rate of 8 mg/kg of body weight. The dose was divided equally into 2 parts, and each part was injected s.c. at the base of an ear. Similar sows (n = 18) served as untreated controls. Of 23 treated sows, 9 passed 37 kidneyworms in urine samples collected daily, within 7 days posttreatment. Results of analysis on urine samples from most treated sows were negative for kidneyworm eggs by posttreatment day 5 and samples from 15 treated sows remained negative for 61 days posttreatment. Hatchability of kidneyworm eggs from treated sows was reduced by posttreatment day 4. Percentage development and survival of larvae to the 3rd stage dropped within 24 h and was 0 by posttreatment day 5 in 11 of 13 treated sows, which continued to pass kidneyworm eggs. Livers from all sows were condemned on slaughter as unfit for human consumption because of kidneyworm lesions. An average of 7 kidneyworms were recovered from the kidneys and ureters of treated sows, and an average of 40 kidneyworms were recovered from the control sows.