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Efflux of tritiated thymidine by erythrocytes from mice infected with trypanosoma brucei brucei



Efflux of tritiated thymidine by erythrocytes from mice infected with trypanosoma brucei brucei



Annals of Tropical Medicine and Parasitology 80(6): 581-586



Erythrocytes from mice infected with Trypanosoma brucei brucei showed a higher rate of efflux of labelled thymidine than did control erythrocytes from uninfected mice (0.56 .+-. 0.10 and 0.38 .+-. 0.06 .mu.mole min-1 ml-1 packed cells respectively). Efflux of the nucleoside from erythrocytes of normal and infected mice were inhibited to the same extent by a specific nucleoside transport inhibitor, nitrobenzylthioinosine. Enumeration of nitrobenzylthioinosine binding sites on the erythrocytes showed that both have similar numbers of sites (6.2-6.6 .times. 103 sites/erythrocyte). It is concluded that the membrane permeability of the erythrocytes from infected mice was affected by the trypanosome in such a way as to enhance the purine nucleoside transport capacity. This may result in an increased supply of vital purine bases and nucleosides to trypanosomes which depend on their hosts for these nutrients.

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