+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Ejection fraction response to exercise in patients with chest pain, coronary artery disease and normal resting ventricular function



Ejection fraction response to exercise in patients with chest pain, coronary artery disease and normal resting ventricular function



Circulation 66(3): 643-648



We studied the ejection fraction (EF) response to upright exercise using first-pass radionuclide angiography (RNA) in 281 patients with chest pain, significant coronary artery disease and normal resting ventricular function. A wide range of resting function (heart rate and EF) and exercise function (heart rate, EF and peak work load) was measured in this population. The EF response to exercise (delta EF) varied widely, ranging from a decrease of 36% to an increase of 26%. Twenty-eight clinical, catheterization and RNA variables were examined to determine their relationship to delta EF. Considered individually, the variables showing the strongest relationship were resting pulse pressure, positive exercise ECG changes and adequate exercise. Multivariable analysis identified resting pulse pressure, adequate exercise, resting EF, the change in end-diastolic volume index with exercise, positive exercise ECG changes and, to a lesser degree, the number of diseased vessels as variables that were significant independent predictors of delta EF. These observations indicate that delta EF is a complex response that is influenced by many pathophysiologic variables in the presence of coronary artery disease. Several of these variables are not related to the extent of coronary artery disease.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 005338481

Download citation: RISBibTeXText

PMID: 7094275

DOI: 10.1161/01.cir.66.3.643


Related references

What is the significance of a decrease in ejection fraction with exercise in patients with coronary artery disease and resting left ventricular dys function?. American Heart Association Monograph (91): II-125, 1982

The ejection fraction response to exercise in patients with coronary artery disease and abnormal left ventricular function. Journal of Nuclear Medicine 23(5): P33, 1982

Ejection fraction response to exercise in patients with chest pain and normal coronary arteriograms. Circulation 64(5): 952-957, 1981

Right ventricular ejection fraction response to exercise in patients with coronary artery disease influence of both right coronary artery disease and exercise induced changes in right ventricular afterload. Journal of the American College of Cardiology 3(4): 895-901, 1984

Value of normal electrocardiographic findings in predicting resting left ventricular function in patients with chest pain and suspected coronary artery disease. American Journal of Medicine 86(6 PART 1): 658-662, 1989

The relation between myocardial ischemia and the ejection fraction response to exercise in patients with normal or abnormal resting left ventricular function. American Heart Journal 109(6): 1253-1258, 1985

Left ventricular ejection fraction change with exercise versus ejection fraction at rest in coronary artery disease: implications for using ejection fraction variations in making therapeutic decisions. American Journal of Therapeutics 11(3): 164-170, 2004

Exercise-induced changes of B-type natriuretic peptide uncover the unknown coronary artery disease in patients with chest pain and normal left ventricular systolic function. European Journal of Cardiovascular Prevention and Rehabilitation 18(1): 72-78, 2011

Mechanism of overshoot elevation of left ventricular ejection fraction during recovery after exercise in normal subjects and patients with coronary artery disease, assessed by 99mTc exercise radionuclide ventriculography. Kaku Igaku. Japanese Journal of Nuclear Medicine 32(10): 1079-1088, 1995

Right ventricular ejection fraction during exercise in normal subjects and in coronary artery disease patients: assessment by multiple-gated equilibrium scintigraphy. Circulation 62(1): 133-140, 1980

Prognostic significance of exercise induced complex ventricular arrhythmias in coronary artery disease patients with normal and abnormal ejection fraction. Chest: 324, 1984

Right ventricular ejection fraction during exercise in normal subjects and in coronary artery disease patients assessment by multiple gated equilibrium scintigraphy. Circulation 62(1): 133-140, 1980

Assessment of right ventricular ejection fraction during exercise in coronary artery disease by multiple-gated equilibrium scintigraphy using continuous infusion of 81mKr: relationship with the location of coronary artery stenosis and left ventricular function. Kaku Igaku. Japanese Journal of Nuclear Medicine 31(2): 163-173, 1994

Response of right ventricular ejection fraction to exercise in patients with coronary artery disease assessment by first pass radio nuclide angio cardiography. Japanese Circulation Journal 47(8): 959-960, 1983

Response of right ventricular ejection fraction to exercise stress in coronary artery disease. Respiration & Circulation 33(1): 69-75, 1985