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Electrophoretic variants of blood proteins in japanese iv. prevalence and enzymologic characteristics of glucose 6 phosphate dehydrogenase variants in hiroshima and nagasaki japan


, : Electrophoretic variants of blood proteins in japanese iv. prevalence and enzymologic characteristics of glucose 6 phosphate dehydrogenase variants in hiroshima and nagasaki japan. Human Genetics 70(2): 101-108

Electrophoretic screening of glucose-6-phosphate dehydrogenase (EC 1.1.1.49, G6PD) was conducted one sample of 9,260 children born to the atomic bomb survivors in Hiroshima (Honshu) and Nagasaki (Kyushu). The prevalence of electrophoretic variants was 0.11% in males and 0.42% in females in Hiroshima, and 0.16% in males and 0.31% in females in Nagasaki. Enzymologic characteristics of 10 variants obtained from three males and seven hemizygous fathers of heterozygous females were examined. As a result, three new types of G6PD variants were identified among five variants detected in Hiroshima, and three new types among five variants in Nagasaki. All the variants except one belong to Class 3, as defined by Yoshida et al. (1971).

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