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Electrophoretic variation for x chromosome linked hypo xanthine phospho ribosyl transferase ec 2.4.2.8 in wild derived mice


, : Electrophoretic variation for x chromosome linked hypo xanthine phospho ribosyl transferase ec 2.4.2.8 in wild derived mice. Genetics 103(4): 785-796

An electrophoretic variation for hypoxanthine phosphoribosyltransferase, HPRT, was identified in samples of Mus spretus, a field mouse from southern Europe and in M. musculus castaneus, a house mouse from southeast Asia. These mice will interbreed with laboratory mice to produce viable, fertile F1 progeny. The variation for HPRT segregates as an X chromosome gene in F1 and backcross progeny. Linkage analysis involving the markers Pgk-1 and Ags indicated a gene order of centromere-Hprt-Pgk-1-ags in crosses involving both stocks of wild mice.

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Related references

Spurna V.; Nebola M.; Siroky J., 1976: Expression of hypo xanthine guanine phospho ribosyl transferase activity in hetero karyons derived from hypo xanthine guanine phospho ribosyl transferase positive and hypo xanthine guanine phospho ribosyl transferase negative mammalian cells. Scripta Medica (Brno) 49(6/7): 341-342

Siroky J.; Spurna V., 1975: Hypo xanthine guanine phospho ribosyl transferase activity in hybrids derived from hypo xanthine guanine phospho ribosyl transferase positive and hypo xanthine phospho ribosyl transferase negative mouse cells. Neoplasma (Bratislava) 22(4): 403-412

Brikun I.A.; Sukhodolets V.V., 1981: Phenotypical properties of escherichia coli k 12 purine auxotrophs with disturbed synthesis of guanine phospho ribosyl transferase xanthine phospho ribosyl transferase and hypo xanthine phospho ribosyl transferase. Purine auxotrophs of E. coli completely blocked for reutilization of guanine, xanthine and hypoxanthine via phosphoribosyltransferase reactions (purD hpt gpt) were studied. These bacteria lack the ability to use inosine as a C and purine source, e...

Emmerson B.T.; Johnson L.A.; Gordon R.B., 1976: Hypo xanthine guanine phospho ribosyl transferase positive and hypo xanthine guanine phospho ribosyl transferase negative erythrocytes in hetero zygotes for hypo xanthine guanine phospho ribosyl transferase deficiency. Journal of Clinical Chemistry & Clinical Biochemistry 14(6): 285

Lacroix S., 1976: Electrophoretic variation in partial deficiencies of hypo xanthine guanine phospho ribosyl transferase. Journal Of Clinical Chemistry & Clinical Biochemistry: 288

Melton D.W., 1981: Cell fusion induced mouse neuro blastoma hypo xanthine phospho ribosyl transferase revertants with variant enzyme and elevated hypo xanthine phospho ribosyl transferase protein levels. Fusion of 6-thioguanine-resistant mouse neuroblastoma to HeLa whole and minicells generated neuroblastoma HPRT [hypoxanthine phosphoribosyl transferase] revertants in addition to true cell hybrids. All revertants contained HPRT with decreased elec...

Van Diggelen O.P.; Shin S I.; Klinger H.P., 1974: Identification of a presumptive structural mutation in hypo xanthine phospho ribosyl transferase in a somatic cell by a new fluorescence method for electrophoresis of hypo xanthine phospho ribosyl transferase allozymes. Genetics 77(1 PT 2): S67

Wilson J.M.; Tarr G.E.; Groebner W.; Zoellner N.; Kelley W.N., 1982: Evidence for an amino acid substitution serine arginine in the hypo xanthine guanine phospho ribosyl transferase variant hypo xanthine guanosine phospho ribosyl transferase munich. Journal of Clinical Chemistry & Clinical Biochemistry 20(6): 437

Lugo T.G.; Baker R.M., 1983: Chromosome mediated gene transfer of hypo xanthine guanine phospho ribosyl transferase and adenine phospho ribosyl transferase in an intraspecific human cell system. Chromosome-mediated transfer of genes between human cell lines was accomplished using HeLa cells as chromosome donors and HT1080 fibrosarcoma lines as recipients. The intraspecific transfer of 2 genetic markers, hypoxanthine-guanine-phosphoribosyl...

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