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Electrophoretically controlled dermal or transdermal application systems with electronic indicators

, : Electrophoretically controlled dermal or transdermal application systems with electronic indicators. International Journal of Pharmaceutics (Kidlington) 36(1): 37-40

The present investigation describes a system for the local application of basic drugs to the skin, using the antihistamine diphenhydramine hydrochloride as an example in which the release of the drug from a gel-type carrier is controlled by a weak electric field. In vitro studies of the release of drug showed that for example, through the application of 9 V, the amount of diphenhydramine hydrochloride released from a gel carrier in 5 min can be increased by a factor of 2.5. A newly developed, pencil-shaped application system contains an integrated voltage supply and an electronic indicator to show when the system is in operation. Investigations in 6 subjects of the current flow and electrical resistance of the human body show that the current through the body caused by the drug pencil is about 86 .mu.A.

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Accession: 005349205

DOI: 10.1016/0378-5173(87)90233-X

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