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Electrophoretically distinct forms of uridine kinase ec 2.7.1.48 in the rat tissue distribution and age dependence


, : Electrophoretically distinct forms of uridine kinase ec 2.7.1.48 in the rat tissue distribution and age dependence. Biochemical Journal 185(1): 273-276

By the use of polyacrylamide-gel electrophoresis, uridine kinase from fetal rat liver was separated into 4 types designated I, II, III and IV in decreasing order of mobility towards the anode. The most anodic (type I) was found only in rapidly growing tissues, such as fetal liver and brain, postnatal spleen and tumor cells. In adult tissues, types II, III and IV were found in the kidney, and types III and IV in the spleen and the liver, whereas type IV was the sole form of uridine kinase present in the brain.

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