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Electrophysical parameters of the growing mycelium of actinomyces nodosus which produce amphotericin b


, : Electrophysical parameters of the growing mycelium of actinomyces nodosus which produce amphotericin b. Antibiotiki (Moscow) 26(5): 349-352

The dielectric constants E1 and impedance Z of the growing mycelium of A. [Streptomyces] nodosus producing amphotericin B were determined with the method of dielectric estimations at 103-108, the concentrations of the biomass and antibiotic being determined simultaneously. The values of the dielectric permeability and impedance may be indicative of the biomass volume and antibiotic accumulation, respectively. It is suggested that standard curves be plotted and the electrophysic parameters be used for automatic and continuous control of the A. nodosus growth. Calculation of the viability coefficient according to B.N. Tarusov showed that it directly correlated with the economic coefficient. It is concluded that additional information on the medium such as the dipole moment, Z-potential and others may be obtained using the electrophysic parameters.

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