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Electrophysiologic and antiarrhythmic efficacy of oral sotalol for sustained ventricular tachyarrhythmias evaluation by programmed stimulation and ambulatory electrocardiogram

, : Electrophysiologic and antiarrhythmic efficacy of oral sotalol for sustained ventricular tachyarrhythmias evaluation by programmed stimulation and ambulatory electrocardiogram. Journal of the American College of Cardiology 8(4): 949-958

Programmed ventricular stimulation and ambulatory electrocardiography were performed both before and during oral sotalol therapy in 39 patients with ventricular tachyarrhythmia inducible by programmed stimulation (sustained ventricular tachycardia [n = 31], ventricular fibrillation [n = 3], nonsustained ventricular tachycardia [n = 5]). Oral sotalol was started at 80 mg twice daily and the dose thereafter was then gradually increased until a mean dose of 300 mg (range 160-480) was reached. In 12 of 34 patients with inducible sustained ventricular tachycardia or fibrillation the arrhythmia was suppressed; in 19 patients it was not and in 3 the spontaneous arrhythmia recurred. Reproducibly inducible nonsustained ventricular tachycardia was suppressed by sotalol in all five patients with this arrhythmia. Thus, a favorable electrophysiologic response was obtained in 17 (44%) of 39 patients. Arrhythmia suppression correlated with the type of arrhythmia (unsustained or sustained) induced during the control period (p < 0.05), and nonresponders had a higher incidence of previously ineffective drug trials (p < 0.05). In 22 patients treated long term with sotalol suppression of arrhythmia inducibility on programmed stimulation predicted freedom from recurrences (16 of 17), whereas continued inducibility indicated drug failure (5 of 5) (p < 0.005). Serial ambulatory electrocardiograms performed in 37 of the 39 patients did not correlate with the results of electrophysiologic testing. For the patients on long-term treatment, invasive testing was superior to electrocardiographic monitoring in predicting outcome. These data indicate that in daily doses of 160 to 480 mg (1) oral sotalol is a very useful agent in patients presenting with sustained ventricular tachycardia or fibrillation, and (2) its efficacy is fairly well predicted by programmed stimulation.

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Accession: 005349240

PMID: 3760368

DOI: 10.1016/s0735-1097(86)80440-5

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López-Gómez, M.; Mediavilla García, J.D.; Bianchi Llave, J.L.; Duro Ruiz, G., 1995: Paralysis of the brachial plexus secondary to pseudotumoral fat necrosis. Medicina Clinica 105(3): 116-116

Bond, G.; Showers, W.; Cheseby, M., 1997: A pervasive millennial-scale cycle in North Atlantic Holocene and glacial climates. Evidence from North Atlantic deep sea cores reveals that abrupt shifts punctuated what is conventionally thought to have been a relatively stable Holocene climate. During each of these episodes, cool, ice-bearing waters from north of Iceland were...

Razenkova N.I.; Morozov V.I.; Samoylova Y.S., 1974: Distribution and forms of lead occurring in secondary dispersion haloes of the Kafan deposit, southeastern Transcaucasia. Izvestiya Vysshikh Uchebnykh Zavedeniy Geologiya i Razvedka

Van Brummelen J., 1992: Ramgea new genus of pezizales from the netherlands. A new ascomycetous genus, Ramgea, related to genera of the Thelebolaceae, is proposed with Ramgea annulispora, spec. nov. as type species.

FARAH, A., 1952: Renal vascular changes produced by the mercurial diuretic salyrgan. Nembutalized dogs were infused with isotonic, hypertonic or hypotonic saline to which adequate amts. of creatinine or inulin and p-aminohippuric acid were added. Varying amts. of salyrgan were given intraven. Blood pressure, renal blood flow, glom...

Sugiyama, E.; Ozawa, T.; Taki, H.; Maruyama, M.; Yamashita, N.; Ohta, M.; Hirata, M.; Kobayashi, M., 2001: Hereditary angioedema with a de novo mutation of exon 8 in the C1 inhibitor gene showing recurrent edema of the hands around the peripheral joints: importance for the differential diagnosis of joint swelling. We describe a patient with hereditary angioedema (HAE), showing recurrent edema around the peripheral joints. Her symptoms began at the age of 18 with hand swelling distal to the wrist joints. Until she was referred to our hospital 3 years after h...

't Hart, L.M.; van Haeften, T.W.; Dekker, J.M.; Bot, M.; Heine, R.J.; Maassen, J.Antonie., 2002: Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell. An association between type 2 diabetes and genetic variation in the KIR6.2 gene has been reported in several populations. Based on in vitro studies with cell lines expressing the Glu(23)Lys (E23K) mutation, it was recently suggested that this muta...

Umiker, W.O.; Bolt, R.J.; Hoekzema, A.D.; Pollard, H.M.rvin, 1958: Cytology in the diagnosis of gastric cancer, the significance of location and pathologic types. The overall accuracy of cytologit diagnosis of 38 gastric cancers by a chymotrypsin lavage technique was 89.5%. There were 2 false positive reports (2.6%). The least satisfactory results were obtained from antral neoplasms while the best results w...

Holík, K.; Rysánek, K.; Parák, S.; Prajsová, R., 1972: Glycogenolysis and lipolysis induced by adrenalin in infectious hepatitis. I. Abnormalities of the glycide metabolism. Vnitrni Lekarstvi 18(8): 737-743

Kilani, M., 1980: Anthelminthic efficacity of Morantel tartrate. Clinical assay in cattle in Tunisia. Recueil de medecine veterinaire 156(4): 299-304