EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiologic and hemodynamic effects after aminophylline endovenous administration in man






Cardiologia (Rome) 32(9): 1005-1007

Electrophysiologic and hemodynamic effects after aminophylline endovenous administration in man

Recent studies found that aminophylline iv induces life-threatening arrhythmias and sudden death. The purpose of this study was to evaluate the effect of iv aminophylline on cardiac arrhythmias on 12 patients mean age 58 years that underwent both hemodynamic and electrophysiologic testing with programmed ventricular stimulation. After control studies, aminophylline was infused using an iv bolus of 5.6 mg/kg after which 0.9 mg/kg/hour was delivered by iv infusion. After aminophylline administration a blood sample was taken to document aminophylline concentration. Drug levels ranged from 9.5-12.0 mg/l. Before and after drug administration were measured the following parameters: left ventricular systolic pressure (LVSP), left ventricular filling pressure (LVFP), mean arterial pressure (MAP), left ventricular dP/dt and totale vascular resistences (TVR). Programmed ventricular stimulation was performed at 600 and 462 ms cycle length and single and double extrastimulus were delivered at the apex of right ventricle. Ventricular repetitive responses were 3 or more beats of intraventricular reentry. Effective refractory period of right ventricle did not change after aminophylline. In 9 patients repetitive ventricular responses were induced after aminophylline. LVSP and MAP were not modified. LVFP and TVR dropped respectively 31.4 and 10.8%. LV dP/dt and Co increased respectively 28.8 and 17.9%. Our findings suggest that therapeutic doses of aminophylline induce ventricular electrical instability in patients already presenting with life-threatening arrhythmias. However aminophylline produces an positive inotropic effect.


Accession: 005349245



Related references

Electrophysiologic and hemodynamic effects of intravenous aminophylline in humans. Cardiologia 32(9): 1005-1007, 1987

Electrophysiologic study of the effects of aminophylline and metaproterenol on canine myocardium. Chest 101(1): 232-238, 1992

An electrophysiologic study of the effects of aminophylline and metaproterenol on canine myocardium. American Review of Respiratory Disease 141(4 PART 2): A502, 1990

Electrophysiologic effects of intravenous aminophylline in heart transplant recipients with sinus node dysfunction. Journal of Heart and Lung Transplantation 14(3): 429-435, 1995

A comparison of the electrophysiologic effects of aminophylline and terbutaline in heart transplant recipients with sinus node dysfunction. Circulation 92(8 SUPPL ): I334, 1995

Comparative electrophysiologic effects of atp and adenosine in the canine heart influence of atropine propranolol vagotomy dipyridamole and aminophylline. American Journal of Cardiology 55(5): 571-576, 1985

Hemodynamic effects of aminophylline in cor pulmondale. Circulation 33(1): 17-25, 1966

Aminophylline counteracts the hemodynamic effects of enoximone. Clinical Pharmacology & Therapeutics 47(2): 140, 1990

Hemodynamic effects of aminophylline in heart failure. American Journal of Cardiology 17(2): 232-239, 1966

Hemodynamic effects of aminophylline in primary pulmonary hypertension. Wiener Klinische Wochenschrift 81(37): 651-653, 1969