+ Translate

Electrophysiologic and hemodynamic effects after aminophylline endovenous administration in man

, : Electrophysiologic and hemodynamic effects after aminophylline endovenous administration in man. Cardiologia (Rome) 32(9): 1005-1007

Recent studies found that aminophylline iv induces life-threatening arrhythmias and sudden death. The purpose of this study was to evaluate the effect of iv aminophylline on cardiac arrhythmias on 12 patients mean age 58 years that underwent both hemodynamic and electrophysiologic testing with programmed ventricular stimulation. After control studies, aminophylline was infused using an iv bolus of 5.6 mg/kg after which 0.9 mg/kg/hour was delivered by iv infusion. After aminophylline administration a blood sample was taken to document aminophylline concentration. Drug levels ranged from 9.5-12.0 mg/l. Before and after drug administration were measured the following parameters: left ventricular systolic pressure (LVSP), left ventricular filling pressure (LVFP), mean arterial pressure (MAP), left ventricular dP/dt and totale vascular resistences (TVR). Programmed ventricular stimulation was performed at 600 and 462 ms cycle length and single and double extrastimulus were delivered at the apex of right ventricle. Ventricular repetitive responses were 3 or more beats of intraventricular reentry. Effective refractory period of right ventricle did not change after aminophylline. In 9 patients repetitive ventricular responses were induced after aminophylline. LVSP and MAP were not modified. LVFP and TVR dropped respectively 31.4 and 10.8%. LV dP/dt and Co increased respectively 28.8 and 17.9%. Our findings suggest that therapeutic doses of aminophylline induce ventricular electrical instability in patients already presenting with life-threatening arrhythmias. However aminophylline produces an positive inotropic effect.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005349245

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Siedek, H.; Reuss, L., 1939: Action of nicotinic acid amide in faulty fat absorption. A case is reported of a man of 50 who had suffered from a duodenal ulcer about 10 years previously, and then developed a condition resembling sprue with failure of fat metabolism and severe diarrhoea. Administration of nicotinic acid amide control...

Mislivec, P. B.; Tuite, J., 1970: Species of Penicillium occurring in freshly-harvested and in stored Dent Corn kernels. Temperature and relative humidity requirements of species of Penicillium isolated from yellow Dent Corn kernels. Results are presented of a survey (1964-68) of P. spp. in maize samples from harvest, cribs, bins and experimental storage tests. b. There was an apparent relationship between temp, and moisture requirements of 14 P. spp. and their occurrence in t...

Platt, T; Brennan, Ca; Butler, Js; Campbell, Da; Sadhale, Pp; Spear, P; Steinmetz, Ej; Wu, Sy; Zalatan, Fm, 1990: Messenger RNA 3 end formation in E. coli and S. cerevisiae. NATO ASI series: Series H: Cell biology9(49): 135-144

Tu, Zheng Jin; Lazowski, Krzysztof W.; Ehlenfeldt, Robert G.; Wu, Guoping; Lin, H. Helen; Kousvelari, Eleni; Ann, David K., 1993: Isoproterenol/tannin-dependent R15 expression in transgenic mice is mediated by an upstream parotid control region. Transgenic mice were used to locate the cis-acting DNA elements that are essential for tissue-specific and inducible expression of the rat proline-rich protein gene, R15. Chimeric genes with up to 10 kb of R15 5'-flanking region fused to chlo...

Jentsch, W.; Herrmann, U.; Schiemann, R.; Wunsche, J.; Hennig, U.; Wittenburg, H., 1991: Studies on the energetic utilization of rations with dried feeds, potatoes, sugar beet, apple pectin and sucrose in growing intact and ileorectostomized pigs. 1. Results of pigs with ileo-rectal anastomoses. Groups of gilts from 50-150 kg with ileo-rectal anastomoses were used to measure energy utilization of raw potatoes, steamed potatoes, raw sugarbeet, steamed sugarbeet, cane sugar or apple pectin given as supplements to basal diets. Precaecal dige...

Suzuki K.; Hino K.; Tomoyasu S.; Tsuruoka N., 1987: Differentiation induction and inhibition of dna synthesis in leukemia cells by cytidine analogues. Experimental Hematology (Charlottesville) 15(5): 488

Appleyard G.; Davis G.B., 1983: Activation of sendai virus infectivity by an enzyme in chicken amniotic fluid. Sendai virus grown in rhesus monkey kidney LLC-MK2 cells is known to have low infectivity, no detectable hemolysing ability and predominantly uncleaved F glycoprotein. Treatment of such virus with chicken amniotic fluid resulted in a 103- to 104-f...

Davies, Huw M. L.; Ren, Pingda; Kong, Norman X.; Sexton, Tammy; Childers, Steven R., 2002: Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters. Iodinated 3beta-aryltropanes functionalized appropriately at the 2beta-, 8- and aryl positions display selective binding to either the dopamine or serotonin transporters.

Anonymous, 2013: MES Activates p53 and Induces G2 Arrest. Exogenous low-intensity electrical stimulation has been used for treatment of various intractable diseases despite the dearth of information on the molecular underpinnings of its effects. Our work and that of others have demonstrated that applied...

Figueiredo, E. R. de jr.., 1942: Uma vespinha prejudicial as orqudeas Eurytoma orchidearum (Westw.). Biologico Sao Paulo, 8: 136-138