EurekaMag.com logo
+ Translate

Electrophysiologic effects and pharmacokinetics of intravenous penticainide (CM 7857)


, : Electrophysiologic effects and pharmacokinetics of intravenous penticainide (CM 7857). European Heart Journal 8(6): 618-623

Penticainide is a new class I antiarrhythmic agent. Its electrophysiological effects and pharmacokinetics properties were studied in 28 patients undergoing endocavitary exploration for paroxysmal supraventricular tachycardia (10 cases), WPW syndrome involving an accessory pathway (5 cases), and unexplained dizziness (13 cases). Increasing doses of penticainide were infused in the first 18 patients (0.12 up to 3.5 mg kg-1). The next ten patient received 4 mg kg-1 over a 30 minute period. Penticainide shortened the sinus cycle length and increased the transnodal conduction time. The vetricular conduction time tended to increase. Atrial functional refractory period increased when atrioventricular nodal and ventricular refractory periods remained unchanged. In patients with previous supraventricular tachycardias all triggered arrhythmias were prevented with dosages higher than 2 mg kg-1 and related blood levels higher than 3 mg l-1. A dose-dependency of plasma and renal clearance was documented. Average Cmax values after 4 mg kg-1 was 7.37 .+-. 1.28 mg l-1. No adverse events occurred during the trial and penticainide proved to be well tolerated.

(PDF 0-2 workdays service)

Accession: 005349279

PMID: 3622542

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Kappenberger L.J.; Munoz A., 1987: Electrophysiologic effects of cm 7857 penticainide in patients with bundle branch block. European Heart Journal 8(ABSTR SUPPL 2): 194

Gautier, P.; Escande, D.; Bertrand, J.P.; Seguin, J.; Guiraudou, P., 1989: Electrophysiological effects of penticainide (CM 7857) in isolated human atrial and ventricular fibers. The intracellular electrophysiological properties of a new antiarrhythmic agent, penticainide (5 .times. 10-6 to 5 .times. 10-5 M) were studied in isolated driven human right atrial appendage and papillary muscle superfused with oxygenated Tyrode&...

Pfisterer, M.; Munoz, A.; Burkart, F., 1988: Hemodynamic effects of penticainide (CM 7857), a novel class I antiarrhythmic drug--comparison with disopyramide. Penticainide (CM 7857) is a new class I antiarrhythmic agent, which has been shown to suppress ventricular arrhythmias by a specific effect on repolarization, shortening the action potential duration. To assess acute hemodynamic effects of pentica...

Gautier, P.; Guiraudou, P.; Pezziardi, F.; Bertrand, J.P.; Gagnol, J.P., 1987: Electrophysiological studies of penticainide (CM 7857), a new antiarrhythmic agent, in mammalian myocardium. The intracellular electrophysiologic properties of a new antiarrhythmic substance, penticainide, were studied in isolated rabbit, dog, and guinea pig myocardial preparations superfused or perfused with oxygenated Tyrode's solution. "Ther...

Kühlkamp, V.; Mewis, C.; Mayer, F.; Seipel, L., 1990: Electrophysiologic effects of penticainide in patients with supraventricular tachycardia. The electrophysiologic effects of the new class-I antiarrhythmic drug pentisomide were investigated after intravenous (5 mg/kg) application in nine patients with atrioventricular nodal reentrant tachycardia and six patients with atrioventricular t...

Berdai, D.; Demotes Mainard, F.; Philip, F.; Vincon, G.; Montels, R.; Necciari, J.; Bannwarth, B., 1994: Influence of food and body weight on the pharmacokinetics of penticainide. The pharmacokinetics of penticainide, a class Ic antiarrhythmic drug, was studied in 16 healthy adults (eight males and eight females) after a single 300-mg oral dose in fasting conditions and with a standard meal. Penticainide concentrations in p...

Sams, R.A.; Gerken, D.F.; Dyke, T.M.; Reed, S.M.; Ashcraft, S.M., 1997: Pharmacokinetics of intravenous and intragastric cimetidine in horses. I. Effects of intravenous cimetidine on pharmacokinetics of intravenous phenylbutazone. Cimetidine was administered intravenously and by the intragastric route to six mares at a dose of 4.0 mg/kg of body weight (bw). Specific and sensitive high performance liquid chromatographic methods for the determination of cimetidine in horse pl...

Zannad, F.; Aliot, E.; Baille, N.; Gilgenkrantz, J.M., 1986: Electrophysiologic effects of intravenous carocainide. The electrophysiological properties of carocainide a new Class I antiarrhythmic agent (Delalande Research Centre) were studied after intravenous injection of 3.5 mg/kg in 5 minutes in 16 patients aged 24 to 66 years. Five minutes after the injecti...

Marchlinski, F.E.; Buxton, A.E.; Waxman, H.L.; Josephson, M.E., 1984: Electrophysiologic effects of intravenous metoprolol. We evaluated the electrophysiologic effects of intravenous metoprolol, a selective beta-1-blocking agent, in 12 patients. Electrophysiologic parameters were measured during the control period, immediately following, and 4 to 6 hours after infusion...

Zhang, S.; Sun, R.L.; Song, Y.C., 1989: Electrophysiologic effects of intravenous propafenone. The electrophysiological effects of intravenous propafenone were studied with programmed electrical stimulation in 31 patients. Among them 29 cases with SVT (including WPW syndrome in 11, paroxysmal AF or Af in 3) and the other two cases were stud...