EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiologic effects and pharmacokinetics of intravenous penticainide (CM 7857)


, : Electrophysiologic effects and pharmacokinetics of intravenous penticainide (CM 7857). European Heart Journal 8(6): 618-623

Penticainide is a new class I antiarrhythmic agent. Its electrophysiological effects and pharmacokinetics properties were studied in 28 patients undergoing endocavitary exploration for paroxysmal supraventricular tachycardia (10 cases), WPW syndrome involving an accessory pathway (5 cases), and unexplained dizziness (13 cases). Increasing doses of penticainide were infused in the first 18 patients (0.12 up to 3.5 mg kg-1). The next ten patient received 4 mg kg-1 over a 30 minute period. Penticainide shortened the sinus cycle length and increased the transnodal conduction time. The vetricular conduction time tended to increase. Atrial functional refractory period increased when atrioventricular nodal and ventricular refractory periods remained unchanged. In patients with previous supraventricular tachycardias all triggered arrhythmias were prevented with dosages higher than 2 mg kg-1 and related blood levels higher than 3 mg l-1. A dose-dependency of plasma and renal clearance was documented. Average Cmax values after 4 mg kg-1 was 7.37 .+-. 1.28 mg l-1. No adverse events occurred during the trial and penticainide proved to be well tolerated.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005349279

PMID: 3622542

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

D'Antiga, L.; Dhawan, A.; Portmann, B.; Francavilla, R.; Rela, M.; Heaton, N.; Mieli-Vergani, G., 2002: Late cellular rejection in paediatric liver transplantation: aetiology and outcome. Background: Acute cellular rejection, though mostly encountered during the first 3 months after liver transplant, may occur later on. Clinical features and outcome of children experiencing late cellular rejection (LCR) have not been described to d...

Ezdakov, Nv, 1975: Effectiveness of using enzyme preparations in the agriculture of the USSR. Zhivotnovudni nauki: 2 (4) 124-127

Mahata, Sushil K.; Mahapatra, Nitish R.; Mahata, Manjula; O'connor, Daniel T., 2003: Cocaine-catestatin co-actions inhibition of nicotinic-cholinergic stimulation of catecholamine secretion and gene transcription. The existing literature reveals both synergistic as well as the antagonistic effects of cocaine and nicotine. We were interested to see how cocaine modulates the effect of catestatin on catecholamine secretion and regulates chromogranin A (CgA: th...

Day, G. S.; Valero, J.; Pare, M., 2003: Priming of visual features in superior colliculus during visual search. The ability to discriminate objects in a visual scene is influenced by our previous experience of similar scenes. When a search involves the discrimination of a target defined by a single visual feature, the target often pops out from the ensemble...

Geistdoerfer, P., 1987: Nouvelles captures et redescription d'un poisson Zoarcidae (Pisces, Periformes, Zoarcoidei) des sites hydrothermaux de la ride du Pacific oriental. Bulletin du Museum National d'Histoire Naturelle Section A Zoologie Biologie et Ecologie Animales. 1986 ; 84: 969-980

Alizon M.A., 1969: Convulsions with a metabolic cause. Revue Medicale de Dijon 4(6): 399-402

Amin, A. R.; Attur, M.; Vyas, P.; Leszcynska Piziak, J.; Levartovsky, D.; Rediske, J.; Clancy, R. M.; Vora, K. A.; Abramson, S. B., 1996: Human neutrophils express mRNA for inducible nitric oxide synthase and exhibit intracellular nitric oxide-dependent autacoid functions upon activation, but lack detectable translated product and nitric oxide synthase enzyme activity. Journal of Investigative Medicine 44(3): 267A

Blumel, W; Ronellenfitsch, M., 1975: Establishment of the plan for land consolidation (with special consideration of the amendment to the consolidation law); legal verdicts. Schriftenreihe fur Flurbereinigung: 63

Dawson, J.; Rordorf Adam, C.; Geiger, T.; Towbin, H.; Kunz, S.; Nguyen, H.; Zingel, O.; Chaplin, D.; Vosbeck, K., 1993: Interleukin-1 production in a mouse tissue chamber model of inflammation II Identification of macrophages as the IL-1 producing cells and the effect of anti-inflammatory drugs. We have used our newly described mouse tissue chamber model (1), to investigate the process of IL-1 production in more detail. The inflammatory reaction in the tissue surrounding the implanted chambers was investigated histologically and by using...

Deere, M.; Dieguez, J.L.; Yoon, S.J.; Hewett-Emmett, D.; de la Chapelle, A.; Hecht, J.T., 1999: Genomic characterization of human DSPG3. DSPG3, the human homolog to chick PG-Lb, is a mejrkp6of the small leucine-rich repeat proteoglycan (SLRP) family, including decorin, biglycan, fibromodulin, and lumican. In contrast to the tissue distribution of the other SLRPs, DSPG3 is predomina...