EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiologic effects of amiodarone experimental and clinical observation relative to serum and tissue drug concentrations


, : Electrophysiologic effects of amiodarone experimental and clinical observation relative to serum and tissue drug concentrations. American Heart Journal 108(4 PART 1): 890-898

Oral amiodarone is a potent antiarrhythmic agent with a slow onset of action. Its electrophysiologic properties following chronic administration are well known, but its acute electrophysiological actions are poorly defined. The objectives of the present study were to correlate the electrophysiologic actions of i.v. amiodarone in humans with the acute and chronic effects of the drug relative to plasma and tissue concentrations of the drug. In humans (n = 10), 5 mg/kg i.v. amiodarone (serum concentration 6.50 .+-. 3.34 .mu.g/ml at 10 min, 2.13 .+-. 0.71 .mu.g/ml at 20 min, n = 7) increased the AH interval by 16.4% (P < 0.005), the antegrade effective refractory period (ERP) of the atrioventricular (AV) node by 14.4% (P < 0.025), and the functional refractory period (FRP) of the AV node of 15.5% (P < 0.005%). The ERP or FRP of the atrium of the right ventricle was not significantly changed; there was no effect on the HV interval or the QT and R-R intervals of the ECG. In rabbits (n = 11) given 10 mg/kg i.v. amiodarone (mean .+-. SD serum concentration 0.49 .+-. 0.17 .mu.g/ml; mean myocardial concentration 7.0 .+-. 1.9 .mu.g/gm, n = 3), there were no significant effects on the ECG intervals. In isolated rabbit sinoatrial (SA) node, atria, and AV node (3 preparations) superfused with 5 x 10-6 M amiodarone (3.41 .mu.g/ml), there was no effect on the action potential duration (APD) or other parameters of the transmembrane potential. Rabbits chronically pretreated with amiodarone (20 mg/kg i.p.) for 3 wk had serum drug concentrations of 0.98 .+-. 0.52 .mu.g/ml (n = 4) and myocardial levels of 11.52 .+-. 7.2 .mu.g/gm at 3 wk and 0.50 .+-. 0.18 .mu.g/ml and 14.8 .+-. 6.4 .mu.g/gm, respectively, at 6 wk. Compared to the values in control series, the spontaneous cycle length of the SA node was prolonged by 24% (P < 0.05) at 3 wk and 35.5% (P < 0.01) at 6 wk. The Vmax was affected in none of the tissues but APD was significantly lengthened in all. In atria the APD was increased by 27.6% (P < 0.01) at 3 wk and 32.8% (P < 0.01) at 6 wk; in ventricular muscle the corresponding values were 11.0% (P < 0.05) and 25.3% (P < 0.01). Major differences were indicated between the chronic and acute electrophysiologic effects of amiodarone, difference which are relevant to the interpretation Of the antiarrhythmic actions of the drug following i.v. and oral administration.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005349286

PMID: 6485999

DOI: 10.1016/0002-8703(84)90451-4

PDF Full Text: Electrophysiologic effects of amiodarone experimental and clinical observation relative to serum and tissue drug concentrations


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Veltmann,. Jr.;Jr, 1984: Reducing effects of mycotoxins through nutrition. Poultry digest 43(507): 190-192

Bezerra, V.Moraes.; Andrade, A.Cristina.de.Souza.; César, C.Comini.; Caiaffa, W.Teixeira., 2015: Unawareness of hypertension and its determinants among 'quilombolas' (inhabitants of 'quilombos' - hinterland settlements founded by people of African origin) living in Southwest Bahia, Brazil. This study sought to evaluate the prevalence of unawareness of arterial hypertension (AH) and associated factors among the quilombola population and to describe aspects of the non-pharmacological management of AH. It involved a cross-sectional stu...

Kucisec, A.; Brinar, P., 1980: Evaluation of the Billroth I method for the treatment of ulcer disease--experience gained by the operation of 2,344 patients. Lijecnicki Vjesnik 102(7-8): 427-431

Schmolke E., 1985: Marshal 25 ec a new insecticide for the control of hop aphids. Biologischen Bundesanstalt Fuer Land- Und Forstwirtschaft (West German Federal Biological Institute For Agriculture And Forestry) Mitteilungen Aus Der Biologischen Bundesanstalt Fuer Land- Und Forstwirtschaft, Berlin-Dahlem, Heft 223 44 Deutsche Pflanzenschutz-Tagung, Giessen, 8 -12 Oktober 1984 (Communications From The Federal Biology Institute For Agriculture And Forestry, Berlin-Dahlem, No 223 44th German Plant Protection Meeting, Giessen, West Germany, Oct 8-12, 1984) Xxxvii+35

Tong, H-Xia.; Lu, C-Wei.; Zhang, J-Hong.; Ma, L.; Zhang, J-Hua., 2007: Combination of gamma-interferon with TRAIL and cisplatin or etoposide induces apoptosis in human neuroblastoma cell line SH-SY5Y. Objective To study the effect of gamma-interferon (IFN gamma), tumor necrosis factor related apoptosis inducing ligand (TRAIL) and cisplatin or etoposide induced apoptosis in human neuroblastoma cell line SH-SY5Y and its possible molecular mechan...

Umemura S., 1987: Recent advances in renal alpha 2 adrenoceptor. Yokohama Medical Journal 38(6): 773-780

Holbrook, R.; Anderson, J.M.; Baird-Parker, A.C., 1969: The performance of a stable version of Baird-Parker's medium for isolating Staphylococcus aureus. A stable version of Baird-Parker's medium has been devised by modifying the method of preparation. Poured plates of the medium can be stored for up to 28 days at 4 degrees C without any loss of selectivity. Its performance is compared with th...

Musholt, T.J.; Musholt, P.B.; Khaladj, N.; Schulz, D.; Scheumann, G.F.W.; Klempnauer, J., 2000: Prognostic significance of RET and NTRK1 rearrangements in sporadic papillary thyroid carcinoma. Background: The expression of RET/PTC chimeras was demonstrated in 10% to 20% of sporadic papillary thyroid carcinomas (PTCs), whereas rearrangements of NTRK1 were detected less frequently. Some investigators have hypothesized that RET/PTC activat...

Liu, F.; Ooi, V.E.C.; Chang, S.T., 1997: Free radical scavenging activities of mushroom polysaccharide extracts. The superoxide and hydroxyl radical scavenging activities of eight mushroom antitumor polysaccharide extracts were investigated using phenazin methosulphate-NADH-nitroblue tetrazolium system and ascorbic acid-Cu-2+-cytochrome C system respectively...

Elias J.G.; Eden D., 1980: High resolution transient birefringence of rod like dna the effect of ionic strength. Federation Proceedings 39(6): ABSTRACT 1459