+ Translate

Electrophysiologic effects of bepridil in normal and infarcted canine myocardium

, : Electrophysiologic effects of bepridil in normal and infarcted canine myocardium. Journal of Cardiovascular Pharmacology 8(5): 957-966

The electrophysiologic effects of bepridil, 10 mg/kg i.v., were determined in normal noninfarcted and in infarcted ventricular myocardium in 8 urethane-anesthetized dogs 4-6 days after anterior myocardial infarction. At drive cycle lengths of 400 and 333 ms, bepridil significantly increased relative (RRP) and effective (ERP) refractory periods in both normal ventricular tissue (mean increases, RRP 7-14%, ERP 5-6%, p less than 0.05-0.01) and in infarcted ventricular tissue (mean increases, RRP 12-15%, ERP 13-14%, p less than 0.01). Bepridil also selectively prolonged the local activation delay in infarcted ventricular myocardium (mean increases 37.5-45.1%, p less than 0.01), while ventricular excitation thresholds were not altered by bepridil in either normal or infarcted myocardium. Before bepridil administration, programmed ventricular stimulation initiated sustained ventricular tachycardias in 6 of the 8 postinfarction dogs tested. After bepridil, 2 of the 6 previously responsive animals were rendered noninducible, 3 animals responded to programmed stimulation with nonsustained tachyarrhythmias of relatively slower rates, and the one remaining dog responded with sustained ventricular tachycardia (VT). These data suggest that increases in refractoriness in both normal noninjured and in ischemically injured ventricular tissue, with a selective delay in conduction in ischemically injured tissue, contribute to the antiarrhythmic actions of bepridil in the setting of myocardial infarction.

(PDF same-day service: $19.90)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005349289

PMID: 2429097

DOI: 10.1097/00005344-198609000-00012

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Gaivoronsky, VI., 1981: Recovery of trichostrongylids and their larvae from sheep abomasums. Byulleten' Vsesoyuznogo Instituta Gel'mintologii, 33-35 No. 27

Hromic, Tatiana, 1999: Foraminiferos bentonicos de canales australes: Canal Kirke, golfo Almirante Montt y seno Ultima Esperanza, XIIa Region, Magallanes y Antartica Chilena. The benthonic foraminifers collected in six samples of marine sediments from Kirke chanel, Almirante Montt gulf and seno Ultima Esperanza, (51degreeS), XIIa Region, Magallanes y Antartica Chilena, were studied. This material was obtained during th...

Scoz, G.; Tria, E., 1937: Ascorbic acid content of the liver of the frog in various experimental conditions. Examination of the liver of the frog showed that the ascorbic acid content fell during fasting and still more when thyroxine was administered during a fast, but rose again when food was given together with di-iodotyrosine.

Anonymous, 1992: Foreign agricultural trade of the United States, fiscal year 1991. This statistical reference summarizes current and historical data on US foreign trade in agricultural products. Tables highlight commodity and country information, including values, quantities, principal markets for agricultural exports, and impor...

Izumi Y., 1979: Influence of forage to concentrate ratio on volatile fatty acid production in the rumen of the cow. Four rumen-fistulated Holstein cows were fed orchardgrass hay, orchardgrass silage or corn silage with 4 levels of forage to concentrate ratios (100:0, 75:25, 50:50 and 25:75 on a dry matter basis). The rations were fed twice daily in equal portio...

Gordiyenko V. V.; Zavgorodnyaya O. V.; Usenko O. V., 1999: Heat flow in Donets Basin. The authors present the Donets Basin heat flow (HF) map compiled by using the results of HF determinations at 4600 points of which 4228 have been used for the first time. Their background and anomalous values are shown and the limits of the occurr...

Revington, M., 1983: Haematology of the racing Thoroughbred in Australia 1: reference values and the effect of excitement. Eight hundred and sixteen blood samples were collected from horses at Sydney race tracks, 1 to 3 h before racing, and subjected to haematological analysis. Haemograms were also performed on 65 blood samples taken from horses at rest in their stall...

Petritschek, A.; Lynen, F.; Belitz, H.-D., 1972: Investigations on bitter peptides. I. Literature review and comparative investigations on the bitter taste of amino acids. In connection with research on bitter peptides, the taste of amino acids was examined. In 0.3$ aqueous solution at pH 7.4 a bitter taste was observed with decreasing intensity in L-tryptophan, L-phenylalanine, L-tyrosine, L-arginine, L-valine, L-l...

Weindling P., 1989: Ernst haeckel darwinismus and the secularization of nature. Moore, J R (Ed ) History, Humanity And Evolution: Essays For John C Greene Xii+429p Cambridge University Press: New York, New York, Usa; Cambridge, England, Uk Illus 311-328

Schreurs, A. J. M., 1997: Reply to the letter to the editors by P. Zanen. European Journal of Clinical Pharmacology 53(3-4): 285-286