+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiologic effects of changrolin on cardiac conduction system in anesthetized rabbits

, : Electrophysiologic effects of changrolin on cardiac conduction system in anesthetized rabbits. Acta Pharmacologica Sinica 8(5): 421-425

The electrophysiologic effects of changrolin (CRL) and procainamide (PA) were evaluated in anesthetized rabbits by His-bundle electrogram and computer controlled stimulation. CRL significantly decreased the mean spontaneous cycle length (SCL) (from 251 .+-. 32 to 240 .+-. 26). Corrected sinus nodal recovery time (SNRTc) had no significant changes during atrial pacing. PA, however, increased SCL and SNRTc. Both drugs definitely prolonged atrial effective refractory period (AERP), atrioventricular nodal functional refractory period (AVNF-RP), ventricular relative, effective and absolute refractory period (VRRP, VERP, VARP), CRL, unlike PA, prolonged atrioventricular nodal conduction time (A-H) (from 54 .+-. 7 to 65 .+-. 9). His-Purkinje system (H-V) (from 22 .+-. 2 to 29 .+-. 3) and ventricular conduction time (V) (from 45 .+-. 5 to 53 .+-. 5). It also increased ventricular threshold current in the late diastole and shifted the ventricular strength-interval (S-1) curve to the right. This finding indicates that CRL decreases ventricular excitability throughout the cardiac cycle. PA only shifted the steep portion of the curve to the right and decreased excitability in the early diastole.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005349290

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Bladeren,P.J.van; Green,J.G.; Bruce,J., 2008: Translating science to nutrition practice from molecules and mechanisms to foods and wellness. This article argues that opportunities and challenges facing modern food science require a multidisciplinary approach. It examines the parallels between the emerging fields of translational medicine and nutrition.

Stokholm, J.; Teasdale, T.W.; Johannsen, P.; Nielsen, J.E.; Nielsen, T.Tolstrup.; Isaacs, A.; Brown, J.M.; Gade, A., 2013: Cognitive impairment in the preclinical stage of dementia in FTD-3 CHMP2B mutation carriers: a longitudinal prospective study. A longitudinal study spanning over 8 years and including 17 asymptomatic individuals with CHMP2B mutations was conducted to assess the earliest neuropsychological changes in autosomal dominant neurodegenerative disease frontotemporal dementia (FTD...

Stauder, H., 1915: Neue mediterrane Lepidopterenformcn. Deutsche Entomologische Zeitschrift Iris, 29 20-34

Ruhela, S..; Chauhan, DK.; Khare, AK., 2005: Biochemical alterations due to Procamallanus infection in cat fish, Clarias batrachus. Journal of Nature Conservation. June; 171: 145-151

Eames, B.F.; Sharpe, P.T.; Helms, J.A., 2001: On the role of Sox9 in cartilage formation. Developmental Biology 235(1): 239, July 1

Hague, B.A.; Hooper,, 1997: Cosmetic dehorning in goats. Objective - This article describes a technique using primary closure when dehorning goats, and report the results of 22 cases. Study Design - Medical records of goats that had cosmetic dehorning were reviewed. Animals or Sample Population - Twenty...

Smith, L.; Osborne, R.F., 2006: Facial sarcoidosis presenting as atypical facial pain. Ear, Nose, & Throat Journal 85(9): 574, 578-574, 578

Leiter, R., 2015: One round. Journal of Palliative Medicine 17(6): 741-742

Rohrig, Ernst, 1966: Growth of young foliage trees in the open air under different light conditions. Umsch Wis Tech: 775

Anonymous, 2013: Of Guinea pigs and gratitude the difficult discourse of clinical trials from the cancer patient perspective. In an ongoing longitudinal qualitative cohort study of cancer patients needs and preferences across the cancer journey, we harvested a subset of accounts pertaining to conversations between patients and their clinicians around clinical trials. Rec...