EurekaMag.com logo
+ Translate

Electrophysiologic effects of changrolin on cardiac conduction system in anesthetized rabbits


, : Electrophysiologic effects of changrolin on cardiac conduction system in anesthetized rabbits. Acta Pharmacologica Sinica 8(5): 421-425

The electrophysiologic effects of changrolin (CRL) and procainamide (PA) were evaluated in anesthetized rabbits by His-bundle electrogram and computer controlled stimulation. CRL significantly decreased the mean spontaneous cycle length (SCL) (from 251 .+-. 32 to 240 .+-. 26). Corrected sinus nodal recovery time (SNRTc) had no significant changes during atrial pacing. PA, however, increased SCL and SNRTc. Both drugs definitely prolonged atrial effective refractory period (AERP), atrioventricular nodal functional refractory period (AVNF-RP), ventricular relative, effective and absolute refractory period (VRRP, VERP, VARP), CRL, unlike PA, prolonged atrioventricular nodal conduction time (A-H) (from 54 .+-. 7 to 65 .+-. 9). His-Purkinje system (H-V) (from 22 .+-. 2 to 29 .+-. 3) and ventricular conduction time (V) (from 45 .+-. 5 to 53 .+-. 5). It also increased ventricular threshold current in the late diastole and shifted the ventricular strength-interval (S-1) curve to the right. This finding indicates that CRL decreases ventricular excitability throughout the cardiac cycle. PA only shifted the steep portion of the curve to the right and decreased excitability in the early diastole.

(PDF 0-2 workdays service)

Accession: 005349290

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Yu, Y.; Yu, F.S.; Gu, P.K.; Jin, Z.J., 1987: Electrophysiologic effects of changrolin on the cardiac conduction system in anesthetized rabbits. Zhongguo Yao Li Xue Bao 8(5): 421-425

L.G.R.; Qian J Q.; L.F.H., 1990: Effects of neferine on the heart conduction system in anesthetized rabbits. Neferine, a bis-benzyl-isoquinoline alkaloid from the seed embryo of Nelumbo nucifera Gaertn, possesses antiarrhythmic action. Its effects on the heart conducting system were investigated in the anesthetized rabbits. The sinus node recovery time a...

Bischoff, K.O.; Hager, W.; Bödeker, K., 1979: Electrophysiologic effects of dobutamine on cardiac conduction system. The electrophysiologic effects of dobutamine (D) (3 and/or 6microgram/kg/min), a new beta1 stimulator, was studied in 12 patients with different disturbances of rhythm (sinus-node dysfunction, AV-block, sinus-bradycardia, paroxysmal tachycardia) u...

Vargas, G.; Akhtar, M.; Damato, A.N., 1975: Electrophysiologic effects of isoproterenol on cardiac conduction system in man. The effects of isoproternol (ISOP) on the functional properties of the A-V conduction system were studied in 16 patients using His-bundle recordings and the atrial extrastimulus technique. In all patients, ISOP at an infusion rate of 1 mcg. per mi...

Bischoff, K.O.; Hager, W.; Bödeker, K., 1981: Electrophysiologic effects of dopamine on the cardiac conduction system. The electrophysiologic effects of dopamine (Dop.) (3 microgram; n = 11) 6 microgram/kg/min; n = 14) were studied in 20 patients (5 females, 15 males) with and without different disturbances of rhythm utilizing His-Bundle electrography and right at...

Horio, Y.; Matsuyama, K.; Rokutanda, M.; Hirata, A.; Okumura, K.; Takaoka, K.; Uchida, H.; Ito, H.; Kugiyama, K.; Morikami, Y., 1984: Electrophysiologic effects of atropine and isoproterenol on the cardiac conduction system in familial amyloid polyneuropathy. In ten patients with familial amyloid polyneuropathy (FAP), the effects of atropine and isoproterenol on the cardiac conduction system were studied using surface electrocardiogram (ECG) and His bundle electrograms. Intravenous administration of at...

Kenneback G.; Bergfeldt L.; Vallin H.; Tomson T.; Edhag O., 1991: Electrophysiologic effects and clinical hazards of carbamazepine treatment for neurologic disorders in patients with abnormalities of the cardiac conduction system. Carbamazepine, a first-line drug for the treatment of epilepsy and neuralgia, may exert hazardous effects on the cardiac conduction system. Standard ECG and long-term ECG monitoring and invasive electrophysiologic testing were carried out in 10 pa...

Qiu, H.Y.; Li, D.J.; Mao, H.Y., 1999: Effects of propafenone on electrophysiologic changes caused by alteration of left ventricular afterload in anesthetized rabbits. To study effects of propafenone (Pro) on ventricular electrophysiologic changes caused by alteration of left ventricular afterload of rabbit heart. Before and after i.v. Pro 3 mg.kg-1, changing afterload of left ventricle (LV), occurrence of ventr...

Kitamura M., 1986: Electrophysiologic evaluation on influence of postural change to cardiac conduction system in man. To evaluate effects of postural change on cardiac conduction system in 59 patients (14 with stick sinus syndrome (SSS), 16 with paroxysmal supraventricular tachycardia (PSVT), 8 with AV block, 5 with ventricular tachycardia, 12 with ventricular an...

Sun, A.S.eng; Zhang, W.; Liu, G.X.ong, 1995: Effects of isorhynchophylline on heart conduction function in anesthetized rabbits. Isorhynchophylline (Isorhy) is one of the major alkaloids extracted from Chinese traditional medicine, Uncaria rhynchophylla (Miq.) Jackson. By using atrial pacing and recording His bundle electrograms, effects of Isorhy on heart conduction functi...