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Electrophysiologic effects of cibenzoline in humans related to dose and plasma concentration

, : Electrophysiologic effects of cibenzoline in humans related to dose and plasma concentration. American Heart Journal 112(2): 333-339

The electrophysiologic effects of a new antiarrhythmic agent, cibenzoline, were investigated in 25 patients with an average age of 62 years. The compound was administered intravenously, as a bolus given over 2 minutes, then as a slow infusion over 40 minutes. Each subject was randomly allocated to receive one of the following four doses: 1.55 mg/kg (six patients), 1.8 mg/kg (six patients), 2.2 mg/kg (six patients), or 2.6 mg/kg (seven patients). Plasma cibenzoline concentrations at these doses were 378 .+-. 80, 525 .+-. 194, 618 .+-. 72, and 731 .+-. 196 ng/ml, respectively. Administration of 1.55 mg/kg cibenzoline significantly shortened the sinus cycle (60 msec on average; p < 0.025) and increased intraatrial (+8 msec; p < 0.05) and His-Purkinje conduction times (HV interval +13 msec; p < 0.001). At 1.80 mg/kg, prolongation occurred in the HV interval (+9 msec; p < 0.02), the duration of the QRS complex (+20 msec; p > 0.05), and the QT interval (+18 msec; p < 0.025). At the higher doses these changes became more marked (maximum increase: HV = +16 msec, p < 0.001; QRS + 25msec; p < 0.001; QT + 26 msec, p < 0.05), and additional effects on atrioventricular nodal conduction time (AH interval + 17 msec; p < 0.05) and atrial (+20 msec; p < 0.05) and ventricular (+10 msec; p > 0.05) effective refractory periods were observed. Prolongation of the QRS duration was the effect that correlated best with plasma cibenzoline levels (r = 0.47; p < 0.05). These results allow an understanding of the antiarrhythmic activity of cibenzoline in humans.

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Accession: 005349291

PMID: 3526853

DOI: 10.1016/0002-8703(86)90271-1

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Bullock, M.A.; Stoker, C.R.; McKay, C.P.; Zent, A.P.; McKay, C.P., 1994: A coupled soil-atmosphere model of H2O2 on Mars. The Viking Gas Chromatograph Mass Spectrometer failed to detect organic compounds on Mars, and both the Viking Labeled Release and the Viking Gas Exchange experiments indicated a reactive soil surface. These results have led to the widespread bel...

FERRERO.P.G.; COMINO.E., 1964: On The Radiological Aspects Of The Thorax After Pulmonary Exeresis Operations. Minerva Radiologica, Fisioterapica E Radiobiologica 16: 249-264

Gautier, H.; Bonora, M., 1980: Possible alterations in brain monoamine metabolism during hypoxia-induced tachypnea in cats. In carotid body-denervated cats, moderate hypoxia, or even normoxia when compared to hyperoxia, provokes a significant depression of the respiratory output. This is observed in conscious or anesthetized or decerebrated animals. On the other hand,...

Cooper, E.D., 1937: III.-Changes in water and chloride content of the tissues in infantile diarrhoea and other conditions. Archives of Disease in Childhood 12(72): 359-368

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Hellman B.; Sehlin J.; Taljedal I.B., 1971: Stereo specific glucose uptake by pancreatic beta cells. Hormone & Metabolic Research 3(3): 219-220

Bernd L.A.G., 1989: Astemizole and terfenadine double blind study in the treatment of chronic urticaria. Two non-sedating antihistamines - astemizole (10 mg daily) and terfenadine (120 mg daily) were compared in a double-blind study in 40 adults suffering from chronic urticaria, lasting 4 weeks. There was a statistically significant decrease in pruri...

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L.D.uarin, N.; L.D.uarin, G.; Renaud, D., 1967: Action of aminoguanidine sulfate on the differentiation in vitro of myocardial cells. Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales 161(4): 910-913