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Electrophysiologic effects of cibenzoline in humans related to dose and plasma concentration

, : Electrophysiologic effects of cibenzoline in humans related to dose and plasma concentration. American Heart Journal 112(2): 333-339

The electrophysiologic effects of a new antiarrhythmic agent, cibenzoline, were investigated in 25 patients with an average age of 62 years. The compound was administered intravenously, as a bolus given over 2 minutes, then as a slow infusion over 40 minutes. Each subject was randomly allocated to receive one of the following four doses: 1.55 mg/kg (six patients), 1.8 mg/kg (six patients), 2.2 mg/kg (six patients), or 2.6 mg/kg (seven patients). Plasma cibenzoline concentrations at these doses were 378 .+-. 80, 525 .+-. 194, 618 .+-. 72, and 731 .+-. 196 ng/ml, respectively. Administration of 1.55 mg/kg cibenzoline significantly shortened the sinus cycle (60 msec on average; p < 0.025) and increased intraatrial (+8 msec; p < 0.05) and His-Purkinje conduction times (HV interval +13 msec; p < 0.001). At 1.80 mg/kg, prolongation occurred in the HV interval (+9 msec; p < 0.02), the duration of the QRS complex (+20 msec; p > 0.05), and the QT interval (+18 msec; p < 0.025). At the higher doses these changes became more marked (maximum increase: HV = +16 msec, p < 0.001; QRS + 25msec; p < 0.001; QT + 26 msec, p < 0.05), and additional effects on atrioventricular nodal conduction time (AH interval + 17 msec; p < 0.05) and atrial (+20 msec; p < 0.05) and ventricular (+10 msec; p > 0.05) effective refractory periods were observed. Prolongation of the QRS duration was the effect that correlated best with plasma cibenzoline levels (r = 0.47; p < 0.05). These results allow an understanding of the antiarrhythmic activity of cibenzoline in humans.

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Accession: 005349291

PMID: 3526853

DOI: 10.1016/0002-8703(86)90271-1

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Hein, G.; Bolwin, R.; Bräuer, R.; Eidner, T.; Franke, S.; Oelzner, P.; Sprott, H., 1995: Rheumatology update--II. Overview of the clinically important status of knowledge and prospects for possible relevant trends in etiopathogenetic research, diagnostic methods and therapeutic possibilities. Medizinische Klinik 90(5): 294-302

Birkhäuser, M., 2002: Depression, menopause and estrogens: is there a correlation?. Women have a higher incidence of depression than men. The lifetime incidence of endogenous depression in women is twice the incidence in males. Because depression in the elderly is an important public health concern, an eventual correlation betwee...

Baak, J.P.A.; Van Diest, P.J., 1993: Quantitative pathology. Burghardt, E [Editor] Surgical gynecologic oncology 21-25

Yen, S.S., 1992: Citation for the Rhône-Poulene Rorer Pharmaceutical Clinical Investigator Award of the Endocrine Society to Samuel S.C. Yen. Endocrinology 131(2): 998-999

Makino, T.; Skretas, G.; Georgiou, G., 2011: Strain engineering for improved expression of recombinant proteins in bacteria. Protein expression in Escherichia coli represents the most facile approach for the preparation of non-glycosylated proteins for analytical and preparative purposes. So far, the optimization of recombinant expression has largely remained a matter o...

Olivier, C.; Rettori, R.; Levy, J.B., 1977: Acute ischemia of inferior limbs in the presence of pathological arteries. Apropos of 205 cases occurring in 197 patients. Chirurgie; Memoires de L'academie de Chirurgie 103(7): 544-551

Shibahara, H.; Sato, I.; Shetty, J.; Naaby Hansen, S.; Herr, J.C.; Wakimoto, E.; Koyama, K., 2002: Two-dimensional electrophoretic analysis of sperm antigens recognized by sperm immobilizing antibodies detected in infertile women. In this study, high resolution two-dimensional (2-D) gel electrophoresis was used to identify human sperm antigens recognized by the sera from infertile women having sperm immobilizing (SI) antibodies. Two-D gel electrophoresis was employed to sep...

Mishima, K.; Kato, Y.; Kaneko, M.Kato.; Nishikawa, R.; Hirose, T.; Matsutani, M., 2006: Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression. Podoplanin (aggrus) is a mucin-like transmembrane sialoglycoprotein that is expressed on lymphatic endothelial cells. Podoplanin is putatively involved in cancer cell migration, invasion, metastasis, and malignant progression and may be involved i...

Birnbaum, L.S.; Thayer, K.A.; Bucher, J.R.; Wolfe, M.S., 2013: Implementing systematic review at the National Toxicology Program: status and next steps. Environmental Health Perspectives 121(4): A108-A109

Coceani, M.; Ciardetti, M.; Schlueter, M.; Palmieri, C.; Santoro, G.; Berti, S., 2013: How should I treat a perimembranous interventricular defect following aortic valve replacement surgery?. A 73-year-old man was admitted to our Institute for repeated episodes of congestive heart failure. The patient was affected by arterial hypertension, dyslipidaemia, severe chronic obstructive pulmonary disease, and recurrent atrial fibrillation. T...