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Electrophysiologic effects of diprafenone in supraventricular and ventricular tachycardia


, : Electrophysiologic effects of diprafenone in supraventricular and ventricular tachycardia. Zeitschrift für Kardiologie 75(12): 757-763

The electrophysiologic effects of diprafenone were evaluated in 31 patients (9 .times. AV nodal reentrant tachycardia, 9 .times. Wolff-Parkinson-White syndrome, 4 .times. paroxysmal atrial fibrillation, 10 .times. recurrent ventricular tachycardia). Electrophysiologic studies were performed before and after intravenous infusion of 1.5 mg/kg body weight diprafenone in a period of 10 minutes. Diprafenone prolonged the mean RR interval during sinus rhythm from 690 .+-. 109 ms to 789 .+-. 93 ms and the maximal sinus node recovery time from 1081 .+-. 216 ms to 1300 .+-. 398 ms (p < 0.001). The effective refractory period of the right atrium increased from 195 .+-. 22 ms to 210 .+-. 28 ms (p < 0.01) and of the right ventricle from 220 .+-. 20 ms to 235 .+-. 20 ms (p < 0.001). Diprafenone produced a prolongation of the antegrade effective refractory period of the AV node from 260 .+-. 35 ms to 294 .+-. 39 ms (p < 0.01) and of the retrograde effective refractory period from 265 .+-. 76 ms to 400 .+-. 130 ms (p < 0.001). The effective refractory periods of the Kent bundle increased: antegrade from 299 .+-. 45 ms to 413 .+-. 133 ms, retrograde from 252 .+-. 33 ms to 286 .+-. 169 ms (p < 0.05). Suppression of inducibility was observed in 12 of 17 patients with supraventricular reentrant tachycardia, in 5 of 8 patients with atrial fibrillation and in 7 of 10 patients with recurrent ventricular tachycardia. The rate of supraventricular tachycardias decreased under the influence of the substance. - Thus, diprafenone is effective in the therapy of patients with recurrent supraventricular and ventricular tachycardia.

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Accession: 005349295

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