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Electrophysiologic effects of ethmozin on sinus node function in patients with and without sinus node dysfunction


, : Electrophysiologic effects of ethmozin on sinus node function in patients with and without sinus node dysfunction. Clinical Cardiology 9(9): 443-448

To compare the effects of ethmozin on sinus node (SN) function in the presence (9 patients) and absence (17 patients) of SN dysfunction, sinus cycle length (SCL), maximal corrected sinus recovery time (CSRT), paced cycle length yielding peak SN suppression, and indirect sinoatrial SA conduction time (SACT) were determined before and after intravenous administration of ethmozin in the dose 2 mg/kg. The mean .+-. SD SCL were significantly shortened in patients with normal SN and were not changed in patients with SN dysfunction after ethmozin administration. The mean maximal CSRT was 252 .+-. 72 before and 284 .+-. 86 ms after ethmozin administration in patients with normal SN function (p < 0.05). In patients with SN dysfunction (p < 0.1) the mean maximal CSRT was found to be 1016 .+-. 434 before and 2170 .+-. 1756 ms after ethmozin administration. The mean SACT was 158 .+-. 41 before and 174 .+-. 51 ms after drug administration in patients with normal SN (p < 0.05). Four out of nine patients with SN dysfunction developed second degree SA exit block after ethmozin administration, whereas SACT increased significantly in the remaining group of patients (180 .+-. 35 to 210 .+-. 32 ms; p < 0.05). The PR, PA, AH, and HV intervals significantly lengthened and the valves of QRS and QT were not changed after ethmozin administration in either group. The conclusion is drawn that ethmozin should be administered cautiously to patients with SN dysfunction, particularly to patients with SA exit block, sinus pauses, or secondary pauses (in particular with bradycardia-tachycardia syndrome).

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Accession: 005349298

PMID: 3530571

DOI: 10.1002/clc.4960090911

PDF Full Text: Electrophysiologic effects of ethmozin on sinus node function in patients with and without sinus node dysfunction


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Thibault, G., 2000: Sodium dodecyl sulfate-stable complexes of echistatin and RGD-dependent integrins: a novel approach to study integrins. This study shows that disintegrins, echistatin as a model, can be used as a radiolabeled probe to simultaneously detect the presence of individual RGD-dependent integrins on cardiac fibroblasts. Binding of (125)I-echistatin to fibroblasts was prop...

Woodell, R., 1987: Birds, butterflies and land use in the Algarve. Cyanopica, 41: 126-129

Schroeder H.; Boyet S.; Nehlig A., 1989: Effects of caffeine and doxapram administration on local cerebral glucose utilization in the rat. The quantitative autoradiographic 2- [14C]deoxyglucose method was applied to the measurement of the effects of a continuous infusion of the respiratory stimulants, caffeine or doxapram at the dose of 18 mg/kg/h on local cerebral glucose utilizatio...

Seegers, W.H.; Heene, D.L.; Marciniak, E., 1966: Activation of purified prothrombin in ammonium sulfate solutions: purification of autoprothrombin C. For the generation of autoprothrombin C activity from prothrombin preparations in concentrated ammonium sulfate solution the optimum conditions were found to be near 2 M at pH 7. In addition to thrombin and autoprothrombin C an inhibitor was obtai...

Hauss W.H., 1979: Possibility of preventing and treating coronary sclerosis and cardiac infarct. Rheinisch Westfaelische Akademie Der Wissenschaften Natur: 7-24

Nabel, E.G.; Nabel, G.J., 2004: Inhibition of vascular smooth muscle cell proliferation administering a thymidine kinase gene. A method for inhibiting restenosis associated with mechanical injury of a blood vessel. An adenoviral vector encoding a suicide gene such as thymidine kinase is directly administered to the injured vessel followed by treatment with a nucleotide an...

Shen D.; Gibaldi M.; Throne M.; Israili Z.; Dayton P.; Mcnay J., 1974: Pharmaco kinetics of bethanidine carbon 14 in hypertensive patients. Pharmacologist 16(2): 219

Orlov, P.A.; Becker, D.; Shewe, G.; Lorz, H., 1999: Cytoplasmic effects on pollen embryogenesis induction in wheat microspore culture. Three alloplasmic wheat lines and the donor of the nuclear genome were tested for their ability for inducing pollen embryogenesis in microspore culture. Cultivation with an initial density of 2 x 105 microspores per ml in C17 medium conditioned by...

Karasu, C.; Altan, V.M., 1994: The role of the endothelium on enhanced contractile response of non-insulin-dependent diabetic rat aortae: effects of insulin treatment. 1. The role of the endothelium on the constrictor effect of noradrenaline (NA), and endothelium-dependent and endothelium-independent vasodilator effects of different agonists were determined in rings of aortae obtained from nondiabetic (control),...

Yagishita, M.; Karasawa, H., 1970: On the bond test between the resin-treated surface layer and the base plywood of the special plywood. Describes a series of tests of bond strength between decorative synthetic surfaces and the plywood base.