+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiologic hemodynamic and metabolic effects of intravenous bepridil hydrochloride

, : Electrophysiologic hemodynamic and metabolic effects of intravenous bepridil hydrochloride. American Journal of Cardiology 55(13 PART 1): 1589-1595

Bepridil, a fast and slow channel blocking drug, was administered i.v. over 5 min in a dose of 3 mg/kg body wt to 19 patients. Ten patients received i.v. bepridil during electrophysiologic study, performed for the investigation of known or suspected cardiac arrhythmias. Sinus cycle length increased from 764 .+-. 56 to 886 .+-. 62 ms. AH [conduction interval] interval increased from 101 .+-. 6.9 to 137 .+-. 11.9 ms. HV [conduction interval] and QRS durations were not significantly affected. QTc interval increased from 395 .+-. 13 to 423 .+-. 13 ms. Atrial effective refractory period increased from 211 .+-. 8 to 242 .+-. 8.7 ms and atrioventricular nodel effective refractory period increased from 299 .+-. 26 to 366 .+-. 30 ms. Right ventricular effective refractory period increased from 233 .+-. 9.3 to 259 .+-. 8.1 ms. In an additional 9 patients with coronary artery disease, a hemodynamic and metabolic study was performed. A transient mean decrease dP/dt max from 1646 .+-. 164 to 1506 .+-. 238 mm Hg/s and a mean increase of 2.6 mm Hg in left ventricular end-diastolic pressure were observed. Both values had returned to control levels 15 min after drug infusion. Blood pressure, cardiac output, coronary sinus blood flow and myocardial lactate extraction ratio did not change significantly. This profile of powerful electrophysiologic and minor hemodynamic changes indicates a potentially useful role for bepridil in the acute management of supraventricular arrhythmias and, possibly, ventricular arrhythmias.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005349337

PMID: 3873868

DOI: 10.1016/0002-9149(85)90978-6

PDF Full Text: Electrophysiologic hemodynamic and metabolic effects of intravenous bepridil hydrochloride

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Baker, J. K. ., 1966: Eurycea troglodytes. Unknown

Bullen, J.J.; Cushnie, G.H.; Stoner, H.B., 1966: Oxygen uptake by Clostridium welchii type A: its possible role in experimental infections in passively immunised animals. British Journal of Experimental Pathology 47(5): 488-506

Cherdshewasart, W.; Sutjit, W.; Pulcharoen, K.; Chulasiri, M., 2010: The mutagenic and antimutagenic effects of the traditional phytoestrogen-rich herbs, Pueraria mirifica and Pueraria lobata. Pueraria mirifica is a Thai phytoestrogen-rich herb traditionally used for the treatment of menopausal symptoms. Pueraria lobata is also a phytoestrogen-rich herb traditionally used in Japan, Korea and China for the treatment of hypertension and a...

Jarvis, C., 1966: Important veterinary and zoological research undertaken at Zoos and Aquaria 1964. International Zoo Yearbook, 6: 457-475

REISS.M.; DAVIS.R.H.; SIDEMAN.M.B.; PLICHTA.E.S., 1963: Pineal Gland And Spontaneous Activity Of Rats. Journal of Endocrinology 28: 127-128

Ferraz, E. S. B., 1976: Sensitivity of the dual gamma energy method for soil density and water content determinations. The principle of the method, the most suitable gamma radiation sources for maximum sensitivity, and the effect of the soil attenuation coefficient on results are discussed with reference to experimental data.

Raskin, L.S.; Akey, L.; Travers, S., 1992: Anterior oral cavity gustatory denervations produce minimal effects on acquisition of aversions to sodium chloride sucrose. Chemical Senses 17(5): 687

Lewthwaite, J.C.; Lamb, K.J.; Wheeler Jones, C.P.D.; Pitsillides, A.A., 2001: Involvement of p38 MAPK in cavitation of synovial joints. Molecular Biology of the Cell 12(Supplement): 461a, Nov

Namdar Irani, M., 1992: The Cauquenes rain-fed zone: a small area in decline?. Chile's extensive rain-fed interior is much less developed than the rest of the country. This paper deals with the main causes of this low level of development, focusing on the history of the agricultural system with the aim of identifying me...

Hoshino T.; Nagai R.; Kataoka M.; Hashimoto T.; Takaba H.; Takahashi H.; Inada K., 1976: Electron microscopic observations on changes of rat mammary tumor and damages of its bone marrow and liver after administrations of mitomycin c. Japanese Journal of Clinical Electron Microscopy 9(5/6): 456-457