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Electrophysiologic hemodynamic and metabolic effects of intravenous bepridil hydrochloride

, : Electrophysiologic hemodynamic and metabolic effects of intravenous bepridil hydrochloride. American Journal of Cardiology 55(13 PART 1): 1589-1595

Bepridil, a fast and slow channel blocking drug, was administered i.v. over 5 min in a dose of 3 mg/kg body wt to 19 patients. Ten patients received i.v. bepridil during electrophysiologic study, performed for the investigation of known or suspected cardiac arrhythmias. Sinus cycle length increased from 764 .+-. 56 to 886 .+-. 62 ms. AH [conduction interval] interval increased from 101 .+-. 6.9 to 137 .+-. 11.9 ms. HV [conduction interval] and QRS durations were not significantly affected. QTc interval increased from 395 .+-. 13 to 423 .+-. 13 ms. Atrial effective refractory period increased from 211 .+-. 8 to 242 .+-. 8.7 ms and atrioventricular nodel effective refractory period increased from 299 .+-. 26 to 366 .+-. 30 ms. Right ventricular effective refractory period increased from 233 .+-. 9.3 to 259 .+-. 8.1 ms. In an additional 9 patients with coronary artery disease, a hemodynamic and metabolic study was performed. A transient mean decrease dP/dt max from 1646 .+-. 164 to 1506 .+-. 238 mm Hg/s and a mean increase of 2.6 mm Hg in left ventricular end-diastolic pressure were observed. Both values had returned to control levels 15 min after drug infusion. Blood pressure, cardiac output, coronary sinus blood flow and myocardial lactate extraction ratio did not change significantly. This profile of powerful electrophysiologic and minor hemodynamic changes indicates a potentially useful role for bepridil in the acute management of supraventricular arrhythmias and, possibly, ventricular arrhythmias.

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Accession: 005349337

PMID: 3873868

DOI: 10.1016/0002-9149(85)90978-6

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Other references

Creutzfeldt O., 1985: Representation of aspects of color and form in the striate and prestriate visual cortex of awake primates. Neuroscience Letters Supplement (22): S585

Gruber, F.; Zamolo, G.; Saftić, M.; Peharda, V.; Kastelan, M., 1999: Treatment of confluent and reticulated papillomatosis with azithromycin. Clinical and Experimental Dermatology 23(4): 191-191

Amon, K.W.; Richards, K.L.; Crawford, M.H., 1984: Usefulness of the postexercise response of systolic blood pressure in the diagnosis of coronary artery disease. The normal decline in systolic blood pressure (SBP) during the recovery phase of treadmill exercise does not occur in some patients with coronary artery disease (CAD). In others the recovery values of SBP exceed the peak exercise values. To examin...

Simons, P.C.; Algra, A.; Bots, M.L.; Banga, J.D.; Grobbee, D.E.; van der Graaf, Y., 1999: Common carotid intima-media thickness in patients with peripheral arterial disease or abdominal aortic aneurysm: the SMART study. Second Manifestations of ARTerial disease. Evidence is emerging that the contribution of atherosclerosis to the development of abdominal aortic aneurysm may differ from that of other manifestations of arterial disease. B-mode ultrasound may be helpful in understanding the characteristics a...

Jennings, K.S.; Sinclair, R.R.; Mohr, C.D., 2016: Who benefits from family support? Work schedule and family differences. Prior research has demonstrated the benefits of family-supportive organization perceptions (FSOP) for reducing stress, increasing satisfaction, and increasing worker commitment; however, less research has studied health outcomes or possible differ...

Malli, H.; Nentwig, W., 1993: Ontogenetic aspects of venom glands and venom of Cupiennius salei. Bulletin de la Societe Neuchateloise des Sciences Naturelles 116(1): 169-175

Kawase, S., 1965: Free amino acids in the hemolymph and midgut epithelium of the silkworm, Bombyx mori (Linnaeus), infected with cytoplasmic-polyhedrosis virus. Free amino acids in the hemolymph and midgut epithelium of the silkworm, Bombyx mori (Linnaeus), infected with the cytoplasmic-polyhedrosis virus were compared with those in the hemolymph and midgut epithelium of the healthy silkworm. Amino-acid a...

Paneth, N.; Susser, M., 1995: Early origin of coronary heart disease (the "Barker hypothesis"). Bmj 310(6977): 411-412

McCarty, G.A., 1991: Autoantibodies in scleroderma and polymyositis: an update. Cutaneous manifestations of systemic connective tissue diseases, such as scleroderma and its variants, polymyositis, and dermatomyositis, often prompt early dermatologic consultation. Indirect immunofluorescent autoantibody determination using tis...

Luciano, A.A.; Lowney, J.; Jacobs, S.L., 1992: Endoscopic treatment of endometriosis-associated infertility. Therapeutic, economic and social benefits. In this report on the therapeutic results in patients with moderate and severe endometriosis treated by operative laser laparoscopy, we also present a comparative analysis of cost and duration of hospitalization and of convalescence in comparable...