+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological actions in mexiletine on rabbit sinoatrial node cells

, : Electrophysiological actions in mexiletine on rabbit sinoatrial node cells. European Journal of Pharmacology 122(1): 11-18

The effects of mexiletine (1-100 .mu.M) were examined on membrane potential and current of rabbit sinoatrial node cells by means of conventional microelectrode and double microelectrode voltage clamp techniques. Mexiletine decreased, in a dose-dependent manner, the maximum rate of depolarization of the action potential and the action potential amplitude, and increased the spontaneous cycle length. The slope of the diastolic depolarization (phase 4) was also reduced. In the voltage clamp experiment, mexiletine (40-100 .mu.M) reduced the slow inward current (Isi), the potassium outward current (Ik) and the hyperpolarization-activated current (Ib). The kinetic variable of IK was not altered by the drug. These results suggest that mexiletine does not have a specific effect on a single-current system but that relatively high concentrations of mexiletine exert an inhibitory effect on the electrical activity of the sinoatrial node cells.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005349376

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Modawi, R. S.; Nour, A. Y. M.; Ahmed, A. H.; Mohammed, A. B.; Ibrahim, A. E. S., 1985: Irrigated summer forages for small dairy farms in the Rahad Agricultural Scheme (Sudan): on-farm trials. The Rahad Agricultural Scheme is devoting 1680 ha to forage production, eventually to be divided into 400 tenancies to aid in supporting about 10 800 cattle. An on-farm trial among 5 of the first tenants in 1982/83 showed that yields of forage sor...

Massobrio, P., 1986: The wine market. On the basis of two surveys, four features of wine production in Italy in the past few years are distinguished: (1) fall in per caput consumption of wine; (2) stagnation in exports; (3) overproduction; and (4) consequent excess of wine production...

Lee C. B.; Williams Harold, 1995: The Teakettle and Carmanville melanges in the Exploits Subzone of Northeast Newfoundland; recycling and diapiric emplacement in an accretionary prism. Special Paper - Geological Association of Canada 41: 147-160

Bortolotti, Gary R.; Negro, Juan J.; Surai, Peter F., 2003: Carotenoids in Eggs and Plasma of Red-Legged Partridges: Effects of Diet and Reproductive Output. Carotenoids are important dietary constituents in birds. They serve as pigments and play numerous physiological roles in both the laying hen and developing embryo. However, factors determining the absorption of carotenoids and their allocation to...

Betit P.; O'rourke P.P., 1988: Pediatric extracorporeal membrane oxygenation for the treatment of a severe pneumonitis. Respiratory Care 33(10): 892, 894

Crosson, C. E.; Gray, T., 1995: Sympatholytic activity of adenosine agonists is dependent on stimulation frequency. Society for Neuroscience Abstracts 21(1-3): 1378

Mcgall, Glenn; Labadie, Jeff; Brock, Phil; Wallraff, Greg; Nguyen, Tiffany; Hinsberg, William, 1996: Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists. High-density arrays of oligonucleotide probes are proving to be powerful new tools for large-scale DNA and RNA sequence analysis. A method for constructing these arrays, using light-directed DNA synthesis with photoactivatable monomers, can curren...

Giglioli, M. E. C., 1965: Micro-projection in reconstruction methods and strippling in the illustration of insect anatomy. Copies of large numbers of serial sections can be accurately and quickly reproduced to any suitable enlargement by micro-projection onto photographic paper. For crude anatomical exhibits, a mosaic print of a median longitudinal section may be moun...

Anonymous, 2012: SIRT7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors mir-125a-5p and mir-125b. Sirtuins are NAD+-dependent deacetylases and function in cellular metabolism, stress resistance and ageing. For Sirtuin7 (SIRT7), a role in ribosomal gene transcription is proposed, but its function in cancer has been unclear. In this study, we sh...

Meireles, M. V.; Paulilo, A. C.; Silva, G. S. Da; Costa, A. J. Da; Junior, L. D.; Machado, R. Z., 1998: Cryptosporidium baileyi experimental infection in broiler chickens: I. Clinical, parasitological and zootechnical aspects. Caged broiler chickens were inoculated by the oral or tracheal route with C. baileyi oocysts, with variation in infective doses for analysis of clinical signs, effects on growth performance and parasitological parameters. One hundred twelve birds...