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Electrophysiological actions of flecainide in normal and infarcted canine Purkinje fibers


European Journal of Pharmacology 112(1): 57-64
Electrophysiological actions of flecainide in normal and infarcted canine Purkinje fibers
The electrophysiological effects of flecainide, 0.1, 0.5 and 1.0 mg/l on action potential characteristics were examined in normal Purkinje fibers and Purkinje fibers surviving infarction, at stimulation cycle lengths of 1000 and 300 ms. Overshoot, amplitude and dV/dtmax [maximal change in volume/maximal change in time] were reduced significantly in a dose-dependent manner by flecainide in both normal Purkinje fibers and Purkinje fibers surviving infarction in dogs. Action potential duration was shortened by flecainide to a greater extent: at the cycle length of 1000 ms compared to 300 ms; at 50% repolarization compared to 90%; and in normal preparations compared to infarcted preparations. Activation time was increased by flecainide in a dose-dependent manner in both types of preparations. This effect was enhanced at the shorter cycle length. In both normal and infarcted preparations, flecainide shortened the ERP [effective refractory period] of those having a longer initial ERP and lengthened those with a shorter ERP. This effect was significant only at the stimulation cycle length of 1000 ms. Flecainide has properties unique and different from traditional antiarrhythmic drugs.


Accession: 005349379

PMID: 4018138



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