EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological analysis of responses to intrinsic nerves in circular muscle of opossum esophageal muscle


, : Electrophysiological analysis of responses to intrinsic nerves in circular muscle of opossum esophageal muscle. American Journal of Physiology 254(1 Pt 1): G107-G116

The nerve-mediated responses to electrical field stimulation (EFS) along the opossum esophageal circular smooth muscle were studied with the sucrose-gap recording technique. Strips from 1-2, 4-5, 7-8, and 10-11 cm above the lower esophageal sphincter were stimulated with short-train (300 ms) and long-train (3 s) durations at 29.degree. C. The response always consisted of a hyperpolarization [inhibitory junction potentials (IJP)] followed by an "off depolarization" often associated with spike potentials and mechanical contraction. Proximal to distal differences in the characteristics of the evoked responses were found, i.e., increasing amplitude, duraiton and time to peak hyperpolarization of the IJP, increasing latency, and amplitude of the off depolarization. Neither atropine, scopolamine, physostigmine, nor guanethidine altered these characteristics substantially, Circular strips of muscularis externa, studied in the organ bath at 37.degree. C using 10-s EFS trains at 5-40 pps, produced off contractions, enhanced by physostigmine and reduced by atropine. High-frequency stimulation occasionally initiated small persistent intrastimulus ("on") responses' some were sensitive to cholingergic agents, but there was no gradient in the delay in their onset. Atropine-insensitive and tetrodotoxin-potentiated transient on responses were occasionally detected. We conclude that only the noncholinergic, nonadrenergic innervation provides a functional intrinsic innervation directly to the oppossum esophagus circular smooth muscle when nerves are activated by EFS.


Accession: 005349401

PMID: 3337229

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Serio R.; Daniel E.E., 1987: On the nature of the intrinsic innervation along the opossum esophageal circular smooth muscle. Clinical & Investigative Medicine 10(4 SUPPL B): B134

Daniel E.E.; Jury J.; Walsh J., 1989: Electrophysiological effects of putative vip antagonists on circular muscle of esophageal body of opossum. Gastroenterology 96(5 PART 2): A109

Decktor, D.L.; Ryan, J.P., 1982: Transmembrane voltage of opossum esophageal smooth muscle and its response to electrical stimulation of intrinsic nerves. Gastroenterology 82(2): 301-308

Decktor D.L.; Ryan J.P., 1982: Trans membrane voltage of opossum didelphis virginiana esophageal smooth muscle and its response to electrical stimulation of intrinsic nerves. The transmembrane potential of esophageal circular smooth muscle was studied before and in response to electrical stimulation of the intrinsic neural plexus. Regional differences were also studied to determine if they are present in these potentia...

Kauvar, D.; Crist, J.; Goyal, R.K., 1989: Effect of cold temperature on membrane potential responses in opossum esophageal circular muscle. The effects of cold temperature on resting membrane potential (RMP) and membrane potential responses to depolarizing electrical current and intramural nerve stimulation were examined in opossum esophageal circular smooth muscle. Intracellular reco...

Serio, R., 1988: Functional intrinsic innervation of the circular smooth muscle of the esophagus in the opossum. Annali Dell'istituto Superiore di Sanita 24(4): 519-521

Prasad, M.; Flamm, S.L.; Saha, J.K.; Goyal, R.K., 2003: The role of Cl- in contractions of the opossum esophageal circular muscle. Journal of General Physiology 122(1): 28a-29a, July

Helm J.F.; Bro S.L., 1988: Response of opossum esophageal circular smooth muscle to tetraethylammonium tea. Gastroenterology 94(5 PART 2): A181

Akbarali, H.I.; Hatakeyama, N.; Wang, Q.; Goyal, R.K., 1995: Transient outward current in opossum esophageal circular muscle. The whole cell patch-clamp technique was used to record a transient outward K+ current (ITO) from single smooth muscle cells isolated from opossum esophageal circular muscle. The threshold for its activation was -50 mV from holding potentials nega...

Akbarali, H.I.; Hatakeyama, N.; Wang, Q.; Saha, J.; Goyal, R.K., 1994: Role of transient outward K+ current in opossum esophageal circular muscle. Biophysical Journal 66(2 PART 2): A327