EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological analysis of the nature of adrenoceptors in the rat basilar artery during development


, : Electrophysiological analysis of the nature of adrenoceptors in the rat basilar artery during development. British Journal of Pharmacology 86(1): 217-228

1 The nature of adrenoceptors in basilar arteries of neonatal rats was investigated by means of electrophysiological techniques. 2 In immature (2-6 day postnatal) rats, micro-injection of noradrenaline elicited a depolarization which consisted of two components. The initial 'fast' component (time to peak of 0.3-4 s) was slightly reduced by phentolamine and was not antagonized by propranolol. The second 'slow' component (time to peak of about 50 s) was not blocked by phentolamine but was antagonized by low concentrations (10-7 M) of propranolol. 3 In immature rats, micro-injection of isoprenaline was more potent than noradrenaline in evoking the 'slow' depolarization but less effective in eliciting the 'fast' response. The pharmacology with respect to adrenoceptor antagonists of both components of the isoprenaline- and noradrenaline-induced depolarizations was similar. There was some evidence of inhibitory .beta.-adrenoceptors in immature rat basilar vessels. 4 In adult rats (6 week old) noradrenaline produced a large 'fast' depolarization which was followed by a 'slow' tail response. Both components were not antagonized by phentolamine or propranolol. 5 It appears that in the basilar artery of neonatal rats there are excitatory .alpha.- and inhibitory .beta.-adrenoceptors but the major responses to noradrenaline and isoprenaline are mediated by .gamma.- and excitatory .beta.-receptors. In adult animals the .gamma.-adrenoceptor predominates. 6 Experiments were carried out in which agonists were applied by ionophoresis. These results confirm the presence of excitatory .beta.-receptors in neonatal basilar vessels and show the response has slow kinetics and it is likely that the .beta.-receptors are distributed uniformly over the smooth muscle surface. In adult animals it was not possible to elicit an excitatory .beta.-receptor-mediated response. 7 The ionophoretic application of noradrenaline never evoked a perceptible depolarization which could be attributed to .gamma.-adrenoceptor stimulation. This result is discussed in terms of receptor distribution with respect to synaptic function in a syncytium.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005349407

PMID: 4052724

DOI: 10.1111/j.1476-5381.1985.tb09452.x

Download PDF Full Text: Electrophysiological analysis of the nature of adrenoceptors in the rat basilar artery during development


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Caviness, V.S.; Sidman, R.L., 1973: Retrohippocampal, hippocampal and related structures of the forebrain in the reeler mutant mouse. Journal of Comparative Neurology 147(2): 235-254

Ståhl, P.L.; Salmén, F.; Vickovic, S.; Lundmark, A.; Navarro, Jé.Fernández.; Magnusson, J.; Giacomello, S.; Asp, M.; Westholm, J.O.; Huss, M.; Mollbrink, A.; Linnarsson, S.; Codeluppi, S.; Borg, Åke.; Pontén, F.; Costea, P.Igor.; Sahlén, P.; Mulder, J.; Bergmann, O.; Lundeberg, J.; Frisén, J., 2016: Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Analysis of the pattern of proteins or messengerRNAs (mRNAs) in histological tissue sections is a cornerstone in biomedical research and diagnostics. This typically involves the visualization of a few proteins or expressed genes at a time. We have...

Cannon, Hl, 1974: Natural toxicants of geologic origin and their availability to man. Environmental Quality and Food Supply P L White and Drobbins eds: 43-164

Vanthournout, S.; Deckers, T.; Valcke, R., 2006: Hormonal balance and physiological background for decision support on fruit set improvement on pear trees. An experiment was conducted on trees of pear cv. Conference to study the effect of prohexadione-Ca and gibberellins on proteomics and gene expression for better understanding of flower initiation and fruit set. The treatments comprised: control (t...

GREENBERG.R.E.; GARDNER.L.I., 1959: The metabolic reaction to infectious disease. Pediatric Clinics of North America 6(1): 139-154

Wang, C.; Daimon, H.; Lee, Y.; Kim, J.; Sun, S., 2007: Synthesis of monodisperse Pt nanocubes and their enhanced catalysis for oxygen reduction. Journal of the American Chemical Society 129(22): 6974-6975

Mahmoud, T.; Shararah, E.; LaBarre, E., 2008: Perspectives on dental practice in Eqypt. The dynamics of modernization that characterize developing countries are reflected in the oral healthcare structure of Egypt. An extensive system of free and government-subsidized care exists along side modern, Western-style care for the affluent....

Hazif-Thomas, C.; Stephan, F.; Walter, M.; Thomas, P., 2016: Negative hallucination, self-onsciousness and ageing. Negative hallucinations are characterized by a defect in perception of an object or a person, or a denial of the existence of their perception. Negative hallucinations create blank spaces, due to both an impossible representation and an incapabili...

Zhang-Xiao-Dan, 2007: A robust watermarking authentication algorithm. A robust watermarking authentication algorithm with the value of visual masking as the quantization size is proposed. The security of it depends on hiding keys instead of quantization steps, which can be published, so that it could avoid some secu...

Ekkati, A.R.; Madiyan, V.; Ravindranathan, K.P.; H Bae, J.; Schlessinger, J.; Jorgensen, W.L., 2011: Aryl Extensions of Thienopyrimidinones as Fibroblast Growth Factor Receptor 1 Kinase Inhibitors. Optimization of thienopyrimidinone derivatives as FGFR1 kinase inhibitors is being pursued. The present results confirm predictions of computational modeling that an aryl subtituent can be introduced at the 2-position in strucure 3. The substituen...