+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological and histochemical studies of cis platinum ototoxicity in guinea pigs

Dokkyo Journal of Medical Sciences 15(1): 23-36

Electrophysiological and histochemical studies of cis platinum ototoxicity in guinea pigs

Electrophysiological and histochemical studies of cis-platinum ototoxicity were performed in guinea pigs in order to clarify its etiology and to furnish data for the prevention of ototoxicity. When the Preyer's reflex of the cis-platinum applied guinea pigs disappeared, their EP decreased to 81% of the original level but CM and N1 decreased to 15.6 and 30.1% respectively. Histochemically, a marked decrease of the nitro-BT reducibility occurred in outer hair cells. This decrease was more prominent towards the upper turns of the cochlea and towards the inner rows of outer hair cells. It is clear from these results that the early stage of cis-platinum ototoxication arises from dysfunction of the outer hair cells.

(PDF 0-2 workdays service: $29.90)

Accession: 005349434

Related references

Ototoxicity of cis-dichlorodiammine platinum (II) in guinea pigs. American Journal of Otolaryngology 4(1): 18-26, 1983

Electrophysiological and histological effects of sodium thiosulfate on cddp ototoxicity in guinea pigs. Journal of Shanghai Medical University 17(6): 418-420, 1990

Cisplatin ototoxicity. An electrophysiological dose-effect study in albino guinea pigs. Hearing Research 124(1-2): 99-107, 1998

Studies on the protective effect of electric current in histamine shock in guinea pigs I Histochemical studies on acetylcholinesterase activity in brain tissue of guinea pigs. 1962

Studies On The Ototoxicity Of Neomycin In Guinea Pigs. Sheng Li Xue Bao 28: 116-129, 1965

Studies on ototoxicity of ribostamycin kanamycin and gentamicin in guinea pigs. Zhongguo Kanfshengsu Zazhi 12(2): 97-100, 1987

Studies on demyelinated peripheral nerves in guinea-pigs with experimental allergic neuritis. A histological and electrophysiological study. II. Electrophysiological observations. Brain 90(2): 313-332, 1967

Comparative studies of ototoxicity of diverse antibiotics in local administration on the internal ear of guinea pigs. Archiv für Klinische und Experimentelle Ohren- Nasen- und Kehlkopfheilkunde 196(2): 169-172, 1970

Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig. Toxicology and Applied Pharmacology 33(2): 320-332, 1975

Histochemical study of the changes in nucleic acids in thyroidectomized guinea pigs, guinea pigs treated with thyroid extract and guinea pigs infected with Mycobacterium tuberculosis and treated and not treated with antibiotics. Studii Si Cercetari de Inframicrobiologie 7(3-4): 537-551, 1956