+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological aspects of benzodiazepine antagonists ro 15 1788 flumazepil and ro 15 3505 ethyl 7 chloro 5 6 dihydro 5 methyl 6 oxo 4h imidazo 1 5 a 1 4 benzodiazepine 3 carboxylate

, : Electrophysiological aspects of benzodiazepine antagonists ro 15 1788 flumazepil and ro 15 3505 ethyl 7 chloro 5 6 dihydro 5 methyl 6 oxo 4h imidazo 1 5 a 1 4 benzodiazepine 3 carboxylate. British Journal of Clinical Pharmacology 18(4): 541-548

The comparative action of 2 specific benzodiazepine antagonists, Ro 15-1788 and Ro 15-3505, was examined in 6 healthy volunteers. Medication was given i.v. in a double-blind cross over pattern, and EEG was recorded throughout each experimental session. Ten min after the injection of one of the antagonists or placebo, midazolam was injected in incremental doses until first signs of drowsiness appeared in the EEG. The EEG was computer analyzed, using adaptive segmentation and time-dependent clustering. Continuous power profiles for various frequency bands, as well as power ratios for the physiological frequency bands (e.g., sigma/alpha power ratio) were generated. Sigma/alpha power ratio was the most sensitive parameter detecting early effects of midazolam on the EEG signal, thus enabling a semi-quantitative titration of the antagonists by midazolam. Ro 15-1788 in doses of 5 mg i.v. was counteracted on average by 7.3 mg midazolam. From the EEG analysis, Ro 15-3505 was at least 4-5 times more potent than Ro 15-1788. [Such selective benzodiazepine antagonists have a highly potential use in controllability of anesthesia and the post-operative period, and as antidotes in cases of overdosage of benzodiazepines.].

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005349465

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Prisadaski, C.; Kostadinov, G., 1980: The determination of the spraying efficiency and spray consumption when spraying grapevines. The aqueous 2% dye solution used was found to have a virtually constant dispersion factor of 0.9 for droplets of up to 1.00 mm on paraffin coated cellophane, that for droplets up to 1.5 mm being 0.85. A television unit was developed which scans th...

Miles, S., 1999: Review of 1998. A full report of the activities of The Game Conservancy Trust and of Game Conservancy Limited during the year 1999 is given.

Anonymous, 2012: Fragments of entomology and parasitology in the western lierature from Cervantes to Saramago. In an attempt to amplify the perspective of allusions made to entomological and parasitological situations in the 2th century Latin American narrative, a total of 25 books written by Jorge Amado (1912-21), Miguel Angel Asturias (1899-1974), Albert...

Staniszkis, O.; Radolinska, M., 1976: Studies on wool growth rate of Romney Marsh sheep in the flock at the Witaszyce Experimental Station. The effect of month and season on wool growth was investigated.

Jung, Sin Ho; Ahn, Chul; Donner, Allan, 2001: Evaluation of an adjusted chi-square statistic as applied to observational studies involving clustered binary data. A simple adjustment to the Pearson chi-square test has been proposed for comparing proportions estimated from clustered binary observations. However, the assumptions needed to assure the validity of this test have not yet been thoroughly addressed...

Koch L.E., 1984: A new species of cormocephalus centipede chilopoda scolopendridae from philip island in the south pacific. C. coynei sp. nov. is described. It is a very large but seldom collected centipede from Philip Island, a small severely eroded island near Norfolk Island in the South Pacific.

Normansell L.; Euken M.; Porter M.; Nemunaitis M.; Pippel D., 1991: Buspirone effects on social emotions in rats and chicks. Society for Neuroscience Abstracts 17(1-2): 878

Anonymous, 2011: Scientists show how gene variant linked to ADHD could operate. A study using mice provides insight into how a specific receptor subtype in the brain could play a role in increasing a person's risk for attention-deficit hyperactivity disorder (ADHD). The research, conducted by the Intramural Research Prog...

Moore, Karen J., 1995: Insight into the microphthalmia gene. The murine microphthalmia gene (mi) is one of the last multi-allelic, classic coat-colour genes to be cloned in the mouse and, similar to many of these genes, encodes an exciting molecule that is involved in multiple developmental processes. The e...

Anonymous, 2011: Matrix configuration and patch isolation influences override the species–area relationship for urban butterfly communities. The aim of this paper is to examine the role of urban public parks in maintaining connectivity and butterfly assemblages. Using a regression framework, we first test the relative importance of park size and isolation in predicting abundance and sp...