+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological aspects of nervous conduction in uremia

Clinical Nephrology 29(5): 253-260
Electrophysiological aspects of nervous conduction in uremia
Some neurophysiological techniques have been employed in clinical nephrology to record abnormalities of nervous conduction in central and peripheral pathways. The electrical monitoring on the peripheral and central nervous systems has allowed the detection of uremic neural injury, the diagnosis of specific electrophysiological abnormalities, the evaluation of various treatments employed and the identification of those abnormalities that uremia can induce. A group of 156 subjects subdivided into four groups were examined: 100 healthy subjects (64 M, 36 F); 56 patients (21 glomerulonephritis, 14 pyelonephritis, 5 nephrolithiasis, 5 polycystic kidney, 4 nephroangiosclerosis, 7 undetermined) with chronic renal failure treated with a conventional low nitrogen diet (CLND, 0.6 g/kg b. w./d. of proteins), 8 of whom passed from CLND to a very low nitrogen diet supplemented with .alpha.-keto-analogues; a group of 22 of these 56 underwent a regular dialysis treatment for 12 to 15 hours/weekly for 40.5 .+-. 10.2 months. Three patietns of the CLND group and 13 patients underwent renal transplantation after a variable period of RDT. In the uremic patients we found different populations of motor unit potentials; a decreased MNCV was found in 35% of the CLND patients, RDT patients had slowed MNCV in 42%. The SNCV was compromised more frequently than the MNCV. An increased duration of evoked potentials was sometimes observed in CLND and RDT patients inducing us to consider this a hallmark of uremic syndrome. The .alpha.-keto-analogues and HD/HP treated patients showed an improvement in several features. The electrophysiological evaluation of the central and peripheral nervous system, using evoked potentials remains informative and relevant to the uremic syndrome, although the etiology and the pathophysiology of the abnormalities are elusive. The analysis of multimodal evoked potentials used to evaluate patients treated by CLND, RDT or transplantation can indicate diffuse structural and/or functional abnormalities depending on the variety of alterations observed.

Accession: 005349466

PMID: 3396225

Related references

Preliminary results in the study of velocity of the nervous conduction in chronic uremia by means of a new electronic apparatus. Giornale di Clinica Medica 53(12): 625-638, 1972

Effects of erythropoietin treatment on central nervous system in uremia Electrophysiology of nerve conduction by magnetic stimulation. Kidney International 43(3): 757-758, 1993

Electrophysiological contribution to nervous conduction in the auditory system. Archiv für Klinische und Experimentelle Ohren- Nasen- und Kehlkopfheilkunde 191(2): 567-572, 1968

Electrophysiological aspects of cardiac rhythmicity and conduction. Journal of the Indiana State Medical Association 56: 159-164, 1963

Electrophysiological aspects of sensory conduction velocity in healthy adults. 1. Conduction velocity from digit to palm, from palm to wrist, and across the elbow, as a function of age. Journal of Neurology, Neurosurgery, and Psychiatry 41(12): 1092-1096, 1978

The nervous manifestations of chronic uremia. Apropos of certain clinical, E.E.G. and neuropathologic aspects. La Presse Medicale 75(48): 2443-2447, 1967

Electrophysiological study of the peripheral nervous system in children. Changes in proximal and distal conduction velocities from birth to age 5 years. Journal of Neurology, Neurosurgery, and Psychiatry 42(8): 753-759, 1979

Electrophysiological estimation of the peripheral nerves conduction parameters and the autonomic nervous system function in the course of amyotrophic lateral sclerosis. Neurologia i Neurochirurgia Polska 39(5): 351-357, 2005

Epithelial conduction in salps. 2. The role of nervous and non-nervous conduction system interactions in the control of locomotion. Journal of Experimental Biology, 80: 241-250, 1979

Electrophysiological aspects of uremic neuropathy. I: electromyography, neural motor and sensory conduction and reflex responses. Revista Clinica Espanola 156(6): 419-425, 1980