+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological characteristics of lorcainide, a new antiarrhythmic drug

International Journal of Clinical Pharmacology, Therapy, and Toxicology 24(1): 26-29
Electrophysiological characteristics of lorcainide, a new antiarrhythmic drug
The electrophysiological characteristics and the antiarrhythmic indication areas of lorcainide were studied by using electrophysiological investigations and clinical studies in patients suffering from sustained arrhythmias. According to the data of the arrhythmia analyses (30 patients) the most important electrophysiological effects of lorcainide are: increase of the effective refractory period of the atria and ventricles; prolongation of the conduction time in the His bundle; prolongation of the refractory period and conduction of the accessory pathways. In the course of clinical studies (55 patients) lorcainide proved to be very effective in treating ventricular arrhythmias and preventing or disrupting ventricular tachyarrhythmic attacks. Lorcainide has a very promising antiarrhythmic effect in the suppression of tachyarrhythmias with accessory pathway conduction, too.

Accession: 005349484

PMID: 3957486

Related references

Electrophysiological effects of lorcainide, a new antiarrhythmic drug. Observations in patients with and without pre-excitation. British Heart Journal 45(3): 292-298, 1981

Electrophysiological effects of a new antiarrhythmic agent, lorcainide, on the isolated cardiac muscle fiber as compared with disopyramide. Journal of Pharmacobio-Dynamics 3(12): 677-685, 1980

Improved synthesis of antiarrhythmic drug lorcainide. Zhongguo Yiyao Gongye Zazhi 21(2): 53-55, 1990

Hyponatremia in patients treated with lorcainide a new antiarrhythmic drug. American Heart Journal 108(6): 1443-1448, 1984

Resistant ventricular arrhythmias treated with lorcainide, a new antiarrhythmic drug. Chest 78(4): 658-660, 1980

Pharmacokinetics of lorcainide, a new antiarrhythmic drug, in patients with cardiac rhythm disorders. American Journal of Cardiology 48(1): 157-163, 1981

New directions in antiarrhythmic drug therapy: the development of a promising new agent, lorcainide. American Journal of Cardiology 54(4): 1b-1b, 1984

Arrhythmogenic effects of toxic concentrations of the antiarrhythmic drug lorcainide on the isolated canine ventricle. Journal of Pharmacology and Experimental Therapeutics 223(2): 547-551, 1982

Electrophysiological effects of bunaftine, an antiarrhythmic drug, on action potential characteristics in ventricular muscle preparations. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 88(1): 1-7, 1986

Rapid and simple method for determination of lorcainide, a new antiarrhythmic drug, and its major metabolite, norlorcainide, by high-performance liquid chromatography. Journal of Chromatography 231(2): 478-484, 1982