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Electrophysiological characteristics of lorcainide, a new antiarrhythmic drug

, : Electrophysiological characteristics of lorcainide, a new antiarrhythmic drug. International Journal of Clinical Pharmacology, Therapy, and Toxicology 24(1): 26-29

The electrophysiological characteristics and the antiarrhythmic indication areas of lorcainide were studied by using electrophysiological investigations and clinical studies in patients suffering from sustained arrhythmias. According to the data of the arrhythmia analyses (30 patients) the most important electrophysiological effects of lorcainide are: increase of the effective refractory period of the atria and ventricles; prolongation of the conduction time in the His bundle; prolongation of the refractory period and conduction of the accessory pathways. In the course of clinical studies (55 patients) lorcainide proved to be very effective in treating ventricular arrhythmias and preventing or disrupting ventricular tachyarrhythmic attacks. Lorcainide has a very promising antiarrhythmic effect in the suppression of tachyarrhythmias with accessory pathway conduction, too.

Accession: 005349484

PMID: 3957486

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Related references

Bär, F.W.; Farré, J.; Ross, D.; Vanagt, E.J.; Gorgels, A.P.; Wellens, H.J., 1981: Electrophysiological effects of lorcainide, a new antiarrhythmic drug. Observations in patients with and without pre-excitation. The electrophysiological effects of the intravenous administration of a new antiarrhythmic drug, lorcainide, were evaluated by programmed electrical stimulation of the heart in 23 patients with atrioventricular conduction disturbances (four patien...

Shigenobu, K.; Atoda, H.; Asano, T.; Kasuya, Y., 1980: Electrophysiological effects of a new antiarrhythmic agent, lorcainide, on the isolated cardiac muscle fiber as compared with disopyramide. Electrophysiological effects of a new antiarrhythmic agent, lorcainide, were studied in the isolated guinea pig ventricular myocardium and were compared with those of disopyramide; some of the experiments were also made by using the canine ventric...

Kong R Z.; Xie Y X., 1990: Improved synthesis of antiarrhythmic drug lorcainide. An improved six-step synthetic process of lorcainide, an antiarrhythmic drug, was reported. The catalytic addition reaction of isopropylamine and methyl acrylate had an advantage of no reaction solvent and shorter reaction time.

Somani P.; Temesy Armos P.N.; Leighton R.F.; Goodenday L.S.; Fraker T.D.Jr, 1984: Hyponatremia in patients treated with lorcainide a new antiarrhythmic drug. The effects of iorcainide, a new antiarrhythmic drug, on serum electrolytes and osmolality are described in a series of 33 patients with organic heart disease and complex ventricular arrhythmias treated with lorcainide. In 8 patients, a mean decre...

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