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Electrophysiological correlates of peroxide damage in guinea pig hippocampus in vitro


, : Electrophysiological correlates of peroxide damage in guinea pig hippocampus in vitro. Brain Research 364(2): 377-381

To study the effects of active oxygen on neuronal electrophysiology, hippocampal brain slices were exposed to hydrogen peroxide plus ferrous sulfate which react to produce hydroxyl free radicals. Analysis of extracellularly recorded somatic and dendritic responses to orthodromic stimulation indicated a decrease in both synaptic efficacy and impairment of action potential generation.

Accession: 005349510

PMID: 3947975

DOI: 10.1016/0006-8993(86)90851-6

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