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Electrophysiological effects of encainide and its metabolites in 11 patients


, : Electrophysiological effects of encainide and its metabolites in 11 patients. Journal of Cardiovascular Pharmacology 7(6): 1077-1082

Encainide is a new antiarrhythmic class IC agent. Eleven patients were given 1 mg/kg of encainide i.v. over a 15-min period. Electrophysiological studies were done before and l h after drug administration. Blood levels of encainide and its principle metabolites O-demethyl-encainide, 3 metoxy-O-demetyl-encainide and N-demethyl-encainide were measured serially after drug administration. Heart rate, blood pressure, and conduction intervals were monitored. Sixty minutes after drug administration there was a marked increase of the QRS, PA, AH, and HV intervals of 28.1% (p less than 0.01), 17.2% (p less than 0.01), 22.4% (p less than 0.01), and 32.2% (p less than 0.01), respectively, and a slight increase of the Wenckebach cycle length of 8% (p less than 0.05). BP, RR, QT, CSNRT, ESACT, ERP, and FRP did not vary significantly. The HV interval already was increased significantly 2 min after drug administration, while AH was not increased until 15 min after drug administration. The average blood levels of encainide and ODE 60 min after drug administration were 0.410 +/- 0.12 and 0.176 +/- 0.09 microgram/ml, respectively (mean +/- SE of the mean). There was a positive correlation between the increase of the AH and the blood level of ODE, which points out the importance of prolonged electrophysiological studies when testing drug with possibly active metabolites.

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Accession: 005349566

PMID: 2418291

DOI: 10.1097/00005344-198511000-00010

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Huizen, T. H. P. van, 1980: Why not use window traps for collecting Coleoptera and other flying insects?. An inexpensive, portable and durable window trap based on designs of J. A. Chapman & J. M. Kinghorn and others has been used successfully by the author to catch flying carabids, and its use is recommended. It consists of a large sheet (about 1...

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Bricout F., 1971: The titration of anti herpes antibodies by indirect hem agglutination in the course of gingivo stomatitis in children. Revue Europeenne D'Etudes Cliniques Et Biologiques: 474-476

Stoermann, B.; Kretschmer, K.; Düber, S.; Weiss, S., 2007: B-1a cells are imprinted by the microenvironment in spleen and peritoneum. B-1a cells are found mainly in the peritoneal cavity of mice but are also present in the spleen. Gene expression profiling defined many genes differentially expressed in B-1a cells from these two sites. To see whether this gene expression pattern...

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Shabanova, M. P.; Kagan, S.; Prilezha Eva, E. N.; Tsymbal, L. V.; Makhlina, E. Ya, 1964: Dependence between the structure of some esters of dialkyldithiophosphoric acids and their toxicity for arthropods and warm-blooded animals. Tr Vses Nauch Issled Inst Zashch Rast (21 1): 114-125